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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Slc26a5tm3Jnz
targeted mutation 3, Jian Zuo
MGI:3834612
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Slc26a5tm3Jnz/Slc26a5tm3Jnz involves: 129S6/SvEvTac * C57BL/6 * FVB/N MGI:3834616


Genotype
MGI:3834616
hm1
Allelic
Composition
Slc26a5tm3Jnz/Slc26a5tm3Jnz
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc26a5tm3Jnz mutation (0 available); any Slc26a5 mutation (54 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hearing/vestibular/ear
• the number of cochlear outer hair cells in the basal cochlear turn is decreased compared to in wild-type mice while stiffness is preserved
• the response magnitude around the outer hair cell resting potential is reduced compared to in wild-type mice
• the gain amplification based on somatic motility is 7.5% of normal
• outer hair cell nonlinear capacitance and electromotility is decreased compared to in wild-type mice
• mice exhibit an increased in compound action potential threshold and tuning is absent compared to in wild-type mice

nervous system
• the number of cochlear outer hair cells in the basal cochlear turn is decreased compared to in wild-type mice while stiffness is preserved
• the response magnitude around the outer hair cell resting potential is reduced compared to in wild-type mice
• the gain amplification based on somatic motility is 7.5% of normal
• outer hair cell nonlinear capacitance and electromotility is decreased compared to in wild-type mice
• mice exhibit an increased in compound action potential threshold and tuning is absent compared to in wild-type mice





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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory