Slc26a5^tm3Jnz
Targeted Allele Detail

Summary

• Symbol: Slc26a5^tm3Jnz
• Name: solute carrier family 26, member 5; targeted mutation 3, Jian Zuo
• MGI ID: MGI:3834612
• Synonyms: Prestin^499KI
• Gene: Slc26a5 Location: Chr5:22015653-22070602 bp, - strand Genetic Position: Chr5, 9.97 cM, cytoband A3
• Alliance: Slc26a5^tm3Jnz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:145297
• Parent Cell Line: CMT-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exon 14 was replaced with one in which the following nucleotide substitutions have been made: codon 499 (GTG->GGG; V499G), codon 501 (TAT->CAT; Y501H), and codon 500 (ATT->ATC); silent I. A floxed neo cassette used for selection was removed by germ line, cre mediated recombination. (J:145297)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc26a5 Mutation: 54 strains or lines available

References

• Original: J:145297 Dallos P, et al., Prestin-based outer hair cell motility is necessary for mammalian cochlear amplification. Neuron. 2008 May 8;58(3):333-9
• All: 4 reference(s)