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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gli2tm1Blnw
targeted mutation 1, Baolin Wang
MGI:3834146
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gli2tm1Blnw/Gli2tm1Blnw involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3834147
cx2
 		Gli2tm1Blnw/Gli2tm1Blnw
Shhtm1Chg/Shhtm1Chg 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3834148


Genotype
MGI:3834147
hm1
Allelic
Composition		 Gli2tm1Blnw/Gli2tm1Blnw
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli2tm1Blnw mutation (0 available); any Gli2 mutation (173 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:145182 )
• homozygotes die in utero

nervous system
abnormal neural tube morphology ( J:145182 )
• slightly enlarged
exencephaly ( J:145182 )
• midbrain exencephaly

craniofacial
abnormal maxillary dental arch morphology ( J:145182 )
• enlarged maxillary arch
abnormal maxillary frontal process morphology ( J:145182 )
• broadened nasal processes

limbs/digits/tail
polydactyly ( J:145182 )
• extra digits on the anterior of each limb

skeleton
abnormal maxillary dental arch morphology ( J:145182 )
• enlarged maxillary arch
abnormal maxillary frontal process morphology ( J:145182 )
• broadened nasal processes

embryo
abnormal neural tube morphology ( J:145182 )
• slightly enlarged

growth/size/body
abnormal maxillary dental arch morphology ( J:145182 )
• enlarged maxillary arch
abnormal maxillary frontal process morphology ( J:145182 )
• broadened nasal processes




Genotype
MGI:3834148
cx2
Allelic
Composition		 Gli2tm1Blnw/Gli2tm1Blnw
Shhtm1Chg/Shhtm1Chg
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli2tm1Blnw mutation (0 available); any Gli2 mutation (173 available)
Shhtm1Chg mutation (2 available); any Shh mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
cellular phenotype ( J:145182 )
N
• normal levels of apoptotic cells in the neural tube

nervous system
nervous system phenotype ( J:145182 )
N
• normal sized neural tube




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory