Analysis Tools
immune system
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• one and four hours post-infection with K. pneumoniae, leukocyte numbers in the peritoneal cavity are increased compared to in similarly treated wild-type mice
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• one and four hours post-infection with K. pneumoniae
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• in vitro, neutrophil killing rates of bacteria are decreased compared to wild-type cells
• however, neutrophils exhibit normal survival, phagocytosis, and intracellular calcium release
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• following infection with K. pneumoniae, mice exhibit increased vascular permeability, increased leukocyte and neutrophil accumulation in the peritoneal cavity, and increased bacterial burden compared to in similarly treated wild-type mice
• mice infected with E. coli exhibit increased colony forming units in the lavage fluid compared to similarly treated wild-type mice
• one hour after intratracheally infection with K. pneumoniae, mice exhibit increased burden in the lungs compared to in similarly treated wild-type mice
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cardiovascular system
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• one hour post-infection with K. pneumoniae, mice exhibit a 30% increase in vascular permeability compared to similarly treated wild-type mice
• however, vascular permeability is normal in unchallenged mice and four hours after infection
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hematopoietic system
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• one and four hours post-infection with K. pneumoniae, leukocyte numbers in the peritoneal cavity are increased compared to in similarly treated wild-type mice
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• one and four hours post-infection with K. pneumoniae
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• in vitro, neutrophil killing rates of bacteria are decreased compared to wild-type cells
• however, neutrophils exhibit normal survival, phagocytosis, and intracellular calcium release
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