Plac8^tm1Bhk
Targeted Allele Detail

Summary

• Symbol: Plac8^tm1Bhk
• Name: placenta-specific 8; targeted mutation 1, Beverly H Koller
• MGI ID: MGI:3834141
• Synonyms: Onzin^-
• Gene: Plac8 Location: Chr5:100701591-100720111 bp, - strand Genetic Position: Chr5, 48.49 cM, cytoband E3
• Alliance: Plac8^tm1Bhk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:145277
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A portion of intron 3 and exon 4 was replaced with a floxed neo cassette. The absence of protein expression was confirmed by western blot analysis on intestine, spleen, and neutrophil extracts. (J:145277)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Plac8 Mutation: 15 strains or lines available

References

• Original: J:145277 Ledford JG, et al., Impaired host defense in mice lacking ONZIN. J Immunol. 2007 Apr 15;178(8):5132-43
• All: 9 reference(s)