Phenotypes associated with this allele

• Allele Symbol: Tg(Myh6-Pln)11Egk
• Allele Name: transgene insertion 11, Evangelia G Kranias
• Allele ID: MGI:3833963
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Pln^tm1Egk/Pln^tm1Egk Tg(Myh6-Pln)11Egk/?	involves: 129S2/SvPas	MGI:5051959

Genotype
MGI:5051959

cx1

• Allelic Composition: Pln^tm1Egk/Pln^tm1Egk; Tg(Myh6-Pln)11Egk/?
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal cardiac muscle contractility ( J:66084 )

• ventricular myocytes exhibit increases in shortening fraction, rates of shortening and de-lengthening following maximal stimulation with the beta adrenergic agonist, isoproterenol, however, these increases are lower than increases experienced by controls

• basal cardiac function is similar to control

abnormal myocardial fiber physiology ( J:66084 )

• maximal isoproterenol stimulation has little effect on the Ca²⁺ amplitude peak and no effect on the decline of Ca²⁺ transient in myocytes

muscle

abnormal cardiac muscle contractility ( J:66084 )

• ventricular myocytes exhibit increases in shortening fraction, rates of shortening and de-lengthening following maximal stimulation with the beta adrenergic agonist, isoproterenol, however, these increases are lower than increases experienced by controls

• basal cardiac function is similar to control