Analysis Tools
hematopoietic system
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• thymocyte apoptosis is decreased in double negative cells compare to in wild-type mice
• however, DN2 cells exhibit normal apoptosis rates
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• thymic hypoplasia is apparent at birth and increases with age unlike in wild-type mice
• mice have 4-fold fewer thymocytes than in wild-type mice
• however, seeding of the thymus is normal
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• mice have 4-fold fewer thymocytes than in wild-type mice
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• the fraction of cycling double negative thymocytes is decreased compared to in wild-type mice
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• bone marrow c-Kit+Lin- progenitor cells co-cultured with OP9-DL1 cells in the presence of Flt3-L and IL7 fail to expand as do normal cells
• bone marrow c-Kit+Lin- progenitor cells co-cultured with OP9-DL1 cells exhibit a 3-fold decrease in proliferation and a 1.4- to 6.5-fold increase in apoptosis compared to wild-type cells
• however, B cells differentiate normally from bone marrow cells co-cultured with OP9 cells in the absence of a Notch ligand
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• DN4 cells are virtually absent in bone marrow cells co-cultures with OP9-DL1 cells at day 12, and only DN1 cells are found in the DN compartment at day 18 unlike similarly treated wild-type cells
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• the absolute number of double negative thymocytes is decreased 3-fold compared to in wild-type mice
• the fractions of DN3 and DN4 thymocytes are decreased 2- and 1.25-fold, respectively, compared to in wild-type mice
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• the absolute number of double positive thymocytes is decreased 4-fold compared to in wild-type mice
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• despite an increase of 184% in the population composition in the thymus, the absolute number of CD8+ thymocytes is decreased 2-fold compared to in wild-type mice
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immune system
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• thymocyte apoptosis is decreased in double negative cells compare to in wild-type mice
• however, DN2 cells exhibit normal apoptosis rates
|
|
• thymic hypoplasia is apparent at birth and increases with age unlike in wild-type mice
• mice have 4-fold fewer thymocytes than in wild-type mice
• however, seeding of the thymus is normal
|
|
• mice have 4-fold fewer thymocytes than in wild-type mice
|
|
• the fraction of cycling double negative thymocytes is decreased compared to in wild-type mice
|
|
• bone marrow c-Kit+Lin- progenitor cells co-cultured with OP9-DL1 cells in the presence of Flt3-L and IL7 fail to expand as do normal cells
• bone marrow c-Kit+Lin- progenitor cells co-cultured with OP9-DL1 cells exhibit a 3-fold decrease in proliferation and a 1.4- to 6.5-fold increase in apoptosis compared to wild-type cells
• however, B cells differentiate normally from bone marrow cells co-cultured with OP9 cells in the absence of a Notch ligand
|
|
• DN4 cells are virtually absent in bone marrow cells co-cultures with OP9-DL1 cells at day 12, and only DN1 cells are found in the DN compartment at day 18 unlike similarly treated wild-type cells
|
|
• the absolute number of double negative thymocytes is decreased 3-fold compared to in wild-type mice
• the fractions of DN3 and DN4 thymocytes are decreased 2- and 1.25-fold, respectively, compared to in wild-type mice
|
|
• the absolute number of double positive thymocytes is decreased 4-fold compared to in wild-type mice
|
|
• despite an increase of 184% in the population composition in the thymus, the absolute number of CD8+ thymocytes is decreased 2-fold compared to in wild-type mice
|
cellular
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• thymocyte apoptosis is decreased in double negative cells compare to in wild-type mice
• however, DN2 cells exhibit normal apoptosis rates
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endocrine/exocrine glands
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• thymocyte apoptosis is decreased in double negative cells compare to in wild-type mice
• however, DN2 cells exhibit normal apoptosis rates
|
|
• thymic hypoplasia is apparent at birth and increases with age unlike in wild-type mice
• mice have 4-fold fewer thymocytes than in wild-type mice
• however, seeding of the thymus is normal
|
|
• mice have 4-fold fewer thymocytes than in wild-type mice
|
|
• the fraction of cycling double negative thymocytes is decreased compared to in wild-type mice
|
