Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm3(HIF1A*)Kael mutation
(1 available);
any
Gt(ROSA)26Sor mutation
(942 available)
Speer6-ps1Tg(Alb-cre)21Mgn mutation
(6 available);
any
Speer6-ps1 mutation
(4 available)
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mortality/aging
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N |
• mice exhibit a normal life span
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liver/biliary system
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• hepatocytes exhibit fine vacuolization unlike in wild-type mice but are otherwise normal
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• moderate and in a microvesicular pattern
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mortality/aging
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• mice die at 6 to 8 weeks of age
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liver/biliary system
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• at 6 weeks, the liver is friable and stippled with irregular yellow spots on a reddish black background unlike in wild-type mice
• hepatic vascularity is increased compared to in wild-type mice
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• in a mixed micro- and macrovesicular steatotic pattern
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hematopoietic system
cardiovascular system
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• hepatic vascularity is increased compared to in wild-type mice
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growth/size/body
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N |
• unlike in Vhltm1Jae/Vhltm1Jae Tg(Alb-cre)21Mgn mice, body weight is normal
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integument
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• of paws and unfurred skin by 4 to 6 weeks of age
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cellular
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm3(HIF1A*)Kael mutation
(1 available);
any
Gt(ROSA)26Sor mutation
(942 available)
Tg(KRT14-cre)1Ipc mutation
(0 available)
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integument
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N |
• mice exhibit a normal skin phenotype
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Analysis Tools