Analysis Tools|
Allele Symbol Allele Name Allele ID |
Gt(ROSA)26Sortm3(HIF1A*)Kael targeted mutation 3, William G Kaelin MGI:3832385 |
||||||||||||||||
| Summary |
3 genotypes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice exhibit a normal life span
|
|
• hepatocytes exhibit fine vacuolization unlike in wild-type mice but are otherwise normal
|
|
• moderate and in a microvesicular pattern
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• mice die at 6 to 8 weeks of age
|
|
• at 6 weeks, the liver is friable and stippled with irregular yellow spots on a reddish black background unlike in wild-type mice
• hepatic vascularity is increased compared to in wild-type mice
|
|
• at 6 weeks of age
|
|
• in a mixed micro- and macrovesicular steatotic pattern
|
|
• hepatic vascularity is increased compared to in wild-type mice
|
| N |
• unlike in Vhltm1Jae/Vhltm1Jae Tg(Alb-cre)21Mgn mice, body weight is normal
|
|
• at 6 weeks of age
|
|
• of paws and unfurred skin by 4 to 6 weeks of age
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 09/30/2025 MGI 6.24 |
|
|
|
||
