Phenotypes associated with this allele

• Allele Symbol: Tg(SFTPC-ITGB6)1Des
• Allele Name: transgene insertion 1, Dean Sheppard
• Allele ID: MGI:3832271
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Itgb6^tm1Des/Itgb6^tm1Des Tg(SFTPC-ITGB6)1Des/?	involves: 129S4/SvJae * C57BL/6 * SJL	MGI:3832436
tg2	Tg(SFTPC-ITGB6)1Des/?	involves: C57BL/6 * SJL	MGI:3832437

Genotype
MGI:3832436

cx1

• Allelic Composition: Itgb6^tm1Des/Itgb6^tm1Des; Tg(SFTPC-ITGB6)1Des/?
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

respiratory system

respiratory system phenotype ( J:51592 )

N • bronchoalveolar lavage abnormalities are largely corrected

respiratory system inflammation ( J:51592 )

• accumulation of lymphocytes around conducting airways and adjacent veins found in 6 of 14 mice examined

• less frequent than in mice only homozygous for Itgb6^tm1Des

immune system

respiratory system inflammation ( J:51592 )

• accumulation of lymphocytes around conducting airways and adjacent veins found in 6 of 14 mice examined

• less frequent than in mice only homozygous for Itgb6^tm1Des

integument

alopecia ( J:51592 )

• inflammatory baldness observed

Genotype
MGI:3832437

tg2

• Allelic Composition: Tg(SFTPC-ITGB6)1Des/?
• Genetic Background: involves: C57BL/6 * SJL

normal phenotype

no abnormal phenotype detected ( J:51592 )

• growth and reproduction are normal

• no gross or histological abnormalities of lungs, heart, liver, kidney, spleen, or intestine