Phenotypes associated with this allele

• Allele Symbol: Tg(CAG-Bgeo,-Fgf4)1Mrt
• Allele Name: transgene insertion 1, Gail Martin
• Allele ID: MGI:3832033
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Tg(CAG-Bgeo,-Fgf4)1Mrt/? Tg(Msx2-cre)5Rem/?	involves: 129P2/OlaHsd	MGI:3832333
cn2	Fgf8^tm1.3Mrt/Fgf8^tm1.4Mrt Tg(CAG-Bgeo,-Fgf4)1Mrt/? Tg(Msx2-cre)5Rem/?	involves: 129P2/OlaHsd	MGI:3832340

Genotype
MGI:3832333

cn1

• Allelic Composition: Tg(CAG-Bgeo,-Fgf4)1Mrt/?; Tg(Msx2-cre)5Rem/?
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

postnatal growth retardation ( J:104411 )

• slower growth rate

limbs/digits/tail

polysyndactyly ( J:104411 )

• additional posterior digit composed of partial or complete metacarpal/metatarsal and 1-2 phalanges

• metacarpal/metatarsal usually fused with equivalent bones of digit V

• additional phalange-like elements between digit V and supernumerary digit in rare cases

• half of hind limbs with a thin digit-like structure ventral to digit I, contains metatarsal and 1-2 phalanges

• distal phalange of extra ventral digit sometimes attached to the distal phalange of digit I

• absence of interdigital programmed cell death

abnormal calcaneum morphology ( J:104411 )

• proximal part of the calcaneus is significantly enlarged

fused tarsal bones ( J:104411 )

• occasionally

abnormal limb development ( J:104411 )

• stylopod and zeugopod are normal

broad limb buds ( J:104411 )

• slightly larger than controls at E11.5

abnormal digit development ( J:104411 )

• supernumerary digit on the posterior side of autopods

• earliest indications at E12.5

vision/eye

eyelid hyperplasia ( J:104411 )

• hyperplasia of the eyelids

reproductive system

abnormal reproductive system morphology ( J:104411 )

• malformation of the external genitalia

embryo

broad limb buds ( J:104411 )

• slightly larger than controls at E11.5

skeleton

abnormal calcaneum morphology ( J:104411 )

• proximal part of the calcaneus is significantly enlarged

fused tarsal bones ( J:104411 )

• occasionally

Genotype
MGI:3832340

cn2

• Allelic Composition: Fgf8^tm1.3Mrt/Fgf8^tm1.4Mrt; Tg(CAG-Bgeo,-Fgf4)1Mrt/?; Tg(Msx2-cre)5Rem/?
• Genetic Background: involves: 129P2/OlaHsd

limbs/digits/tail

limbs/digits/tail phenotype ( J:104411 )

N • reversal of abnormalities resulting from loss of Fgf8 alone

N • deltoid tuberosity is normal

polysyndactyly ( J:104411 )

• phenotype due to conditional over expression of Fgf4 retained

fused tarsal bones ( J:104411 )

abnormal limb development ( J:104411 )

abnormal limb bud morphology ( J:104411 )

abnormal digit development ( J:104411 )

growth/size/body

postnatal growth retardation ( J:104411 )

vision/eye

abnormal eyelid morphology ( J:104411 )

reproductive system

abnormal reproductive system morphology ( J:104411 )

embryo

abnormal limb bud morphology ( J:104411 )

skeleton

fused tarsal bones ( J:104411 )