Phenotypes associated with this allele

• Allele Symbol: F7^{tm1(tTA,tetO-F7)Edr}
• Allele Name: targeted mutation 1, Elliot D Rosen
• Allele ID: MGI:3831192
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	F7^tm1(tTA,tetO-F7)Edr/F7^tm1(tTA,tetO-F7)Edr	B6.129X1-F7^tm1(tTA,tetO-F7)Edr	MGI:3831194
hm2	F7^tm1(tTA,tetO-F7)Edr/F7^tm1(tTA,tetO-F7)Edr	involves: 129X1/SvJ * C57BL/6	MGI:3831193
ht3	F7^tm1(tTA,tetO-F7)Edr/F7^tm1Pec	involves: 129X1/SvJ * C57BL/6	MGI:3831196

Genotype
MGI:3831194

hm1

• Allelic Composition: F7^{tm1(tTA,tetO-F7)Edr}/F7^{tm1(tTA,tetO-F7)Edr}
• Genetic Background: B6.129X1-F7^{tm1(tTA,tetO-F7)Edr}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal circulating protein level ( J:144540 )

• thrombin/antithrombin complex concentrations are reduced

• zymogen levels of F8, F9, F11, and F12 are reduced

abnormal blood coagulation ( J:144540 )

increased partial thromboplastin time ( J:144540 )

• activated partial thromboplastin time is prolonged

increased prothrombin time ( J:144540 )

• prothrombin time is prolonged

cardiovascular system

cardiac fibrosis ( J:144540 )

• fibrotic areas of the heart are seen in resting mice

• fibrosis is seen by 2 months of age and becomes progressively more severe

heart hemorrhage ( J:144540 )

• areas of bleeding are seen in the subepicardium and myocardium

Genotype
MGI:3831193

hm2

• Allelic Composition: F7^{tm1(tTA,tetO-F7)Edr}/F7^{tm1(tTA,tetO-F7)Edr}
• Genetic Background: involves: 129X1/SvJ * C57BL/6

mortality/aging

mortality/aging ( J:144540 )

N • unlike mice homozygous for a null allele, survival of homozygotes is similar to wild-type mice

Genotype
MGI:3831196

ht3

• Allelic Composition: F7^{tm1(tTA,tetO-F7)Edr}/F7^tm1Pec
• Genetic Background: involves: 129X1/SvJ * C57BL/6

mortality/aging

premature death ( J:144540 )

• about 50% of mice die between 3 and 10 weeks of age