Analysis Tools
mortality/aging
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• dead embryos are found in a ratio of 1 to 4 at the time of collection of mouse embryonic fibroblasts
• no mice survive to be born
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Allele Symbol Allele Name Allele ID |
Tgfbr1tm1Bopa targeted mutation 1, Boris Pasche MGI:3831090 |
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| Summary |
5 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• dead embryos are found in a ratio of 1 to 4 at the time of collection of mouse embryonic fibroblasts
• no mice survive to be born
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice develop twice as many intestinal tumors as in ApcMin heterozygotes
• mice develop small and predominantly scattered tumors in the small intestine as well as colonic tumors
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• 3 mice develop large, polyploidy and ulcerated colonic tumors
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• mice develop twice as many intestinal tumors as in ApcMin heterozygotes
• mice develop small and predominantly scattered tumors in the small intestine as well as colonic tumors
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• 3 mice develop large, polyploidy and ulcerated colonic tumors
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• only 40% of mice present with neoplastic or metaplastic pancreatic lesions
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• decrease in proliferating cell nuclear antigen (PCNA) staining throughout the entire pancreas
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• expansion of CD8+ population in mesenteric lymph nodes
• total T-cell infiltration near pancreatic lesions is increased, with strong CD8+ infiltration but almost completely absent CD3/pSMAD2+ and CD3/FOXP3+ cell (suppressive/anergic regulatory T lymphocytes) infiltration, indicating a cytotoxic response against pancreatic lesions
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• expansion of CD8+ population in mesenteric lymph nodes
• total T-cell infiltration near pancreatic lesions is increased, with strong CD8+ infiltration but almost completely absent CD3/pSMAD2+ and CD3/FOXP3+ cell (suppressive/anergic regulatory T lymphocytes) infiltration, indicating a cytotoxic response against pancreatic lesions
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• only 40% of mice present with neoplastic or metaplastic pancreatic lesions
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice are protected against pancreatic lesion formation
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• mice are protected against pancreatic lesion formation
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice develop twice as many intestinal tumors as in ApcMin heterozygotes
• mice develop small and predominantly scattered tumors in the small intestine as well as colonic tumors
|
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• 3 mice develop large, polyploidy and ulcerated colonic tumors
|
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• mice develop twice as many intestinal tumors as in ApcMin heterozygotes
• mice develop small and predominantly scattered tumors in the small intestine as well as colonic tumors
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• 3 mice develop large, polyploidy and ulcerated colonic tumors
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• mouse embryonic fibroblasts treated with TGFbeta exhibit a reduced decrease in proliferation compared to similarly treated wild-type mice
• proliferation of intestinal crypt epithelium is increased compared to in wild-type mice
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| N |
• despite disruptions in cell proliferation, hematopoiesis is normal
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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