Analysis Tools
mortality/aging
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• mice die within 1 to 2 hours of birth
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growth/size/body
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• mice are small at birth
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homeostasis/metabolism
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• unlike in wild-type mice, dye is readily absorbed through the paws, facial skin, ear buds and lower belly
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integument
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• mice exhibit focal gaps in the epithelial sheets of the epidermis due to degeneration of cells
• however, desmosomes are still present in normal numbers
• intercellular junctions are perturbed unlike in wild-type epidermis
• adherence and tight junction components fail to localize to cell borders unlike in wild-type epidermis
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• the typically columnar orientation of cells within the basal layer and flattened squamous morphology of the suprabasal cells are lost
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• cells in the spinous layer fail to flatten as in wild-type mice
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• the typically columnar orientation of cells within the basal layer and flattened squamous morphology of the suprabasal cells are lost
• unlike in wild-type mice, cells within condensed nuclei indicating apoptosis are found in the suprabasal layer
• suprabasal keratin intermediate filament organization is perturbed compared to in wild-type mice
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blistering
(
J:144091
)
|
• around the mouth, umbilicus and tail
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flaky skin
(
J:144091
)
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• ventrally
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shiny skin
(
J:144091
)
tight skin
(
J:144091
)
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• skin is inflexible
|
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• mice exhibit increased apoptosis in the epidermis compared to wild-type mice
• however, cell proliferation in the epidermis is normal, and no inflammatory response is observed
|
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• unlike in wild-type mice, dye is readily absorbed through the paws, facial skin, ear buds and lower belly
|
