About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Il17ftm1Yiw
targeted mutation 1, Yoichiro Iwakura
MGI:3830035
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Il17ftm1Yiw/Il17ftm1Yiw involves: 129P2/OlaHsd * C57BL/6 MGI:3830058
cx2
 		Il17ftm1Yiw/Il17ftm1Yiw
Il1rntm1Yiw/Il1rntm1Yiw 		involves: 129 * BALB/c MGI:3830054
cx3
 		Il17atm1Yiw/Il17atm1Yiw
Il17ftm1Yiw/Il17ftm1Yiw
Il1rntm1Yiw/Il1rntm1Yiw 		involves: 129 * BALB/c MGI:3830055
cx4
 		Il17atm1Yiw/Il17atm1Yiw
Il17ftm1Yiw/Il17ftm1Yiw 		involves: 129P2/OlaHsd * C57BL/6 MGI:3830059


Genotype
MGI:3830058
hm1
Allelic
Composition		 Il17ftm1Yiw/Il17ftm1Yiw
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il17ftm1Yiw mutation (0 available); any Il17f mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased susceptibility to bacterial infection ( J:143719 )
• a substantially greater number of bacteria are detected in the colon 7 to 21 days after oral infection with C. rodentium than in controls
• remarkable hypertrophy of the colon and spleen occurs after infection with C. rodentium
• C. rodentium infection leads to more severe histopathology of the colon, and significantly increases crypt length




Genotype
MGI:3830054
cx2
Allelic
Composition		 Il17ftm1Yiw/Il17ftm1Yiw
Il1rntm1Yiw/Il1rntm1Yiw
Genetic
Background		 involves: 129 * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il17ftm1Yiw mutation (0 available); any Il17f mutation (27 available)
Il1rntm1Yiw mutation (0 available); any Il1rn mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
rheumatoid arthritis ( J:143719 )
• mice develop autoimmune arthritis of the joints though with about 20% less incidence than in mice homozygote for just the Il1rntm1Yiw allele

skeleton
rheumatoid arthritis ( J:143719 )
• mice develop autoimmune arthritis of the joints though with about 20% less incidence than in mice homozygote for just the Il1rntm1Yiw allele




Genotype
MGI:3830055
cx3
Allelic
Composition		 Il17atm1Yiw/Il17atm1Yiw
Il17ftm1Yiw/Il17ftm1Yiw
Il1rntm1Yiw/Il1rntm1Yiw
Genetic
Background		 involves: 129 * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il17atm1Yiw mutation (0 available); any Il17a mutation (22 available)
Il17ftm1Yiw mutation (0 available); any Il17f mutation (27 available)
Il1rntm1Yiw mutation (0 available); any Il1rn mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
rheumatoid arthritis ( J:143719 )
• only about 20% of mice develop arthritis compared to almost the 100% incidence of arthritis in mice homozygote for just the Il1rntm1Yiw allele
• severity of disease of those affected is also significantly less than Il1rntm1Yiw homozygotes

skeleton
rheumatoid arthritis ( J:143719 )
• only about 20% of mice develop arthritis compared to almost the 100% incidence of arthritis in mice homozygote for just the Il1rntm1Yiw allele
• severity of disease of those affected is also significantly less than Il1rntm1Yiw homozygotes




Genotype
MGI:3830059
cx4
Allelic
Composition		 Il17atm1Yiw/Il17atm1Yiw
Il17ftm1Yiw/Il17ftm1Yiw
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il17atm1Yiw mutation (0 available); any Il17a mutation (22 available)
Il17ftm1Yiw mutation (0 available); any Il17f mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased susceptibility to bacterial infection ( J:143719 )
• a substantially greater number of bacteria are detected in the colon 7 to 21 days after oral infection with C. rodentium
• remarkable hypertrophy of the colon and spleen occurs after infection with C. rodentium
• C. rodentium infection leads to more severe histopathology of the colon than controls, and significantly increases crypt length




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory