Phenotypes associated with this allele

• Allele Symbol: Tg(YAC46)668Hay
• Allele Name: transgene insertion 688, Michael Hayden
• Allele ID: MGI:3829794
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Htt^tm1Hay/Htt^tm1Hay Tg(YAC46)668Hay/0	involves: FVB/N	MGI:5298849
tg2	Tg(YAC46)668Hay/?	involves: FVB/N	MGI:4881525

Genotype
MGI:5298849

cx1

• Allelic Composition: Htt^tm1Hay/Htt^tm1Hay; Tg(YAC46)668Hay/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:67366 )

N • embryonic lethality observed in Htt^tm1Hay homozygotes is rescued

reproductive system

reproductive system phenotype ( J:67366 )

N • female mice are fertile

male infertility ( J:67366 )

♂

Genotype
MGI:4881525

tg2

• Allelic Composition: Tg(YAC46)668Hay/?
• Genetic Background: involves: FVB/N

nervous system

nervous system phenotype ( J:55405 )

N • no neuronal degeneration is seen at 12 months of age

abnormal long-term potentiation ( J:55405 )

• by 10 months of age, LTP is not induced in CA1 neurons

• glutamate-mediated calcium influx does not occur in CA1 neurons

decreased post-tetanic potentiation ( J:55405 )

• posttetanic potentiation is reduced in 10 month old mutants, indicating impaired presynaptic release

behavior/neurological

behavior/neurological phenotype ( J:55405 )

N • normal motor and behavior function up to 20 months of age