Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Alx4Lst-2J mutation
(1 available);
any
Alx4 mutation
(20 available)
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limbs/digits/tail
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• homozygotes have polydactyly on all four feet
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skeleton
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• homozygotes can have large bulges at the anterior skull, above the snout, indicating defective calvaria formation
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integument
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• homozygotes have dorsal alopecia
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craniofacial
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• homozygotes can have large bulges at the anterior skull, above the snout, indicating defective calvaria formation
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vision/eye
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• craniofacial abnormalities of homozygotes includes wide-set eyes
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growth/size/body
mortality/aging
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• litters from heterozgyous intercrosses often have pups that die perinatally, but a few homozygotes do survive to adulthood
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Alx4Lst-2J mutation
(1 available);
any
Alx4 mutation
(20 available)
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vision/eye
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• at E18.5, fetuses exhibit failure of eyelid closure
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craniofacial
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• at E18.5, frontonasal development is relatively normal; the premaxilla appears normally developed
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Alx4Lst-2J mutation
(1 available);
any
Alx4 mutation
(20 available)
|
|
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limbs/digits/tail
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• preaxial polydactyly on one hind limb is often found
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craniofacial
growth/size/body
vision/eye
limbs/digits/tail
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Alx1em1Jian mutation
(0 available);
any
Alx1 mutation
(22 available)
Alx4Lst-2J mutation
(1 available);
any
Alx4 mutation
(20 available)
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craniofacial
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• at E18.5, the presphenoid bone in the cranial base is severely malformed
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• at E18.5, the premaxilla is severely malformed
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• at E10.5, a clear reduction of Pax7 expression is observed in the caudal region of the lateral nasal process (LNP); both Lhx6 and Lhx8 mRNAs show higher ectopic expression in the caudal region of the LNP than in Alx1em1Jian homozygotes
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• at E18.5, severe notching of the upper lip is observed
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• at E18.5, the philtrum is further shortened relative to Alx1em1Jian homozygotes
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• at E18.5, the nasal bridge is severely widened
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• at E18.5, the nasal bridge is severely depressed
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growth/size/body
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• at E18.5, severe notching of the upper lip is observed
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• at E18.5, the philtrum is further shortened relative to Alx1em1Jian homozygotes
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• at E18.5, the nasal bridge is severely widened
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• at E18.5, the nasal bridge is severely depressed
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skeleton
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• at E18.5, the presphenoid bone in the cranial base is severely malformed
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• at E18.5, the premaxilla is severely malformed
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respiratory system
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• at E18.5, the nasal bridge is severely widened
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• at E18.5, the nasal bridge is severely depressed
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Alx1em1Jian mutation
(0 available);
any
Alx1 mutation
(22 available)
Alx4Lst-2J mutation
(1 available);
any
Alx4 mutation
(20 available)
|
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craniofacial
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• at E18.5, the premaxilla is severely malformed
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• at E10.5, the domain of Pax7 expression is severely reduced while the domain of ectopic expression of both Lhx6 and Lhx8 mRNAs is further expanded in the lateral nasal process (LNP)
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• at E10.5, ectopic activation of Lhx6 and Lhx8 expression is observed in the medial nasal processes (MNP)
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• at E18.5, a wide midline cleft of the upper lip and nose is observed
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• at E18.5, an overt midline facial cleft is observed, with a wide gap separating the rudimentary nasal structures
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growth/size/body
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• at E18.5, a wide midline cleft of the upper lip and nose is observed
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• at E18.5, an overt midline facial cleft is observed, with a wide gap separating the rudimentary nasal structures
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skeleton
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• at E18.5, the premaxilla is severely malformed
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