All Phenotypes Tg(CAG-Bgeo,-Spry2,-ALPP)1Mrt MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(CAG-Bgeo,-Spry2,-ALPP)1Mrt
transgene insertion 1, Gail R Martin
MGI:3829033

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Pten^tm2.1Ppp/Pten^tm2.1Ppp Tg(CAG-Bgeo,-Spry2,-ALPP)1Mrt/0 Tg(Osr1-cre)4Mrt/0	involves: 129P2/OlaHsd * 129S1/Sv * FVB/N	MGI:5467306
cn2	Mesp1^tm2(cre)Ysa/Mesp1⁺ Tg(CAG-Bgeo,-Spry2,-ALPP)1Mrt/0	involves: C57BL/6NCrlj * CBA/JNCrlj	MGI:3829045
cn3	Pax3^tm1(cre)Joe/Pax3⁺ Tg(CAG-Bgeo,-Spry2,-ALPP)1Mrt/0	Not Specified	MGI:3829044

Allelic Composition	Pten^tm2.1Ppp/Pten^tm2.1Ppp Tg(CAG-Bgeo,-Spry2,-ALPP)1Mrt/0 Tg(Osr1-cre)4Mrt/0
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pten^tm2.1Ppp mutation (0 available); any Pten mutation (81 available)
Tg(CAG-Bgeo,-Spry2,-ALPP)1Mrt mutation (1 available)
Tg(Osr1-cre)4Mrt mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased prostate intraepithelial neoplasia incidence ( J:192348 )

• PIN is seen in 15% of prostate ducts as early as 2 weeks of age, in 31% of ducts at 4 weeks, and 42% of ducts at 9 months of age

reproductive system

increased prostate intraepithelial neoplasia incidence ( J:192348 )

• PIN is seen in 15% of prostate ducts as early as 2 weeks of age, in 31% of ducts at 4 weeks, and 42% of ducts at 9 months of age

endocrine/exocrine glands

increased prostate intraepithelial neoplasia incidence ( J:192348 )

• PIN is seen in 15% of prostate ducts as early as 2 weeks of age, in 31% of ducts at 4 weeks, and 42% of ducts at 9 months of age

Allelic Composition	Mesp1^tm2(cre)Ysa/Mesp1⁺ Tg(CAG-Bgeo,-Spry2,-ALPP)1Mrt/0
Genetic Background	involves: C57BL/6NCrlj * CBA/JNCrlj

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mesp1^tm2(cre)Ysa mutation (1 available); any Mesp1 mutation (17 available)
Tg(CAG-Bgeo,-Spry2,-ALPP)1Mrt mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal cardiac epithelial to mesenchymal transition ( J:143444 )

abnormal cardiac outflow tract development ( J:143444 )

• at E9.5 the outflow tract is significantly shorter compared to controls and at an obtuse angle to the right ventricle

• defects in endothelial to mesenchymal transformation and in cardiac neural crest invasion

• decreased proliferation of ISL1 expressing cells

abnormal heart morphology ( J:143444 )

• 75% of mice have heart defects, most of which are arterial pole abnormalities

persistent truncus arteriosus ( J:143444 )

• seen in 3 of 13 mutants

abnormal heart development ( J:143444 )

• decreased proliferation of ISL1 expressing cells in the second heart field

double outlet right ventricle ( J:143444 )

atrioventricular septal defect ( J:143444 )

• seen in 5 of 13 mutants

ventricular septal defect ( J:143444 )

• seen in 9 of 13 mutants

bicuspid aortic valve ( J:143444 )

• seen in 4 of 13 mutants

Allelic Composition	Pax3^tm1(cre)Joe/Pax3⁺ Tg(CAG-Bgeo,-Spry2,-ALPP)1Mrt/0
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax3^tm1(cre)Joe mutation (1 available); any Pax3 mutation (50 available)
Tg(CAG-Bgeo,-Spry2,-ALPP)1Mrt mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

short mandible ( J:143444 )

• at E16.5

short snout ( J:143444 )

• at E16.5

cardiovascular system

cardiovascular system phenotype ( J:143444 )

N	• despite overexpression in neural crest cells, no defects in outflow tract development are seen

skeleton

short mandible ( J:143444 )

• at E16.5

growth/size/body

short snout ( J:143444 )

• at E16.5

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