Phenotypes associated with this allele

• Allele Symbol: Gimap5^tm1Wlr
• Allele Name: targeted mutation 1, Hartmut Weiler
• Allele ID: MGI:3828512
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gimap5^tm1Wlr/Gimap5^tm1Wlr	either: B6.129-Gimap5^tm1Wlr or C.129-Gimap5^tm1Wlr	MGI:3828851

Genotype
MGI:3828851

hm1

• Allelic Composition: Gimap5^tm1Wlr/Gimap5^tm1Wlr
• Genetic Background: either: B6.129-Gimap5^tm1Wlr or C.129-Gimap5^tm1Wlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased survivor rate ( J:143620 )

premature death ( J:143620 )

• reduced life span

• deaths as early as 5 weeks

• substantial mortality between 10 and 20 weeks

• only one of 35 survived beyond 42 weeks

hematopoietic system

abnormal erythrocyte morphology ( J:143620 )

abnormal erythropoiesis ( J:143620 )

abnormal erythrocyte cell number ( J:143620 )

decreased hematocrit ( J:143620 )

• hematocrit mildly reduced

abnormal hemoglobin content ( J:143620 )

anisocytosis ( J:143620 )

• heterogeneity of red blood cell size

thrombocytopenia ( J:143620 )

• mild thrombocytopenia in younger but not in older mice

abnormal leukocyte morphology ( J:143620 )

abnormal CD8-positive, alpha-beta T cell differentiation ( J:143620 )

• deficient mauration of CD8+ T cells in the thymus

increased granulocyte number ( J:143620 )

• 3.8 fold increase in granulocytes

abnormal lymphocyte cell number ( J:143620 )

• 1.6 fold reduction of peripheral lymphocytes

decreased B cell number ( J:143620 )

• reduced B220 and CD19+ B cells in the spleen, pancreatic and inguinal lymph nodes

decreased NK cell number ( J:143620 )

• numbers significantly reduced in bone marrow and the spleen

decreased T cell number ( J:143620 )

• 9 fold reduction in T cell number in the spleen, pancreatic and inguinal lymph nodes

decreased CD4-positive, alpha-beta T cell number ( J:143620 )

• 2 fold reduction in CD4+ cells in the spleen, pancreatic and inguinal lymph nodes

• 8 fold increase in apoptotic cells in the spleen, pancreatic and inguinal lymph nodes

decreased CD8-positive, alpha-beta T cell number ( J:143620 )

• 20 fold reduction in CD8+ cells in the spleen, pancreatic and inguinal lymph nodes

• 4 fold increase in apoptotic cells in the spleen, pancreatic and inguinal lymph nodes

decreased NK T cell number ( J:143620 )

• numbers significantly reduced in bone marrow and the spleen

abnormal spleen morphology ( J:143620 )

• abnormalities in spleen morphology are less pronounced than those seen in the liver

spleen hypoplasia ( J:143620 )

• splenic cellularity reduced 2 fold

immune system

abnormal leukocyte morphology ( J:143620 )

abnormal CD8-positive, alpha-beta T cell differentiation ( J:143620 )

• deficient mauration of CD8+ T cells in the thymus

increased granulocyte number ( J:143620 )

• 3.8 fold increase in granulocytes

abnormal lymphocyte cell number ( J:143620 )

• 1.6 fold reduction of peripheral lymphocytes

decreased B cell number ( J:143620 )

• reduced B220 and CD19+ B cells in the spleen, pancreatic and inguinal lymph nodes

decreased NK cell number ( J:143620 )

• numbers significantly reduced in bone marrow and the spleen

decreased T cell number ( J:143620 )

• 9 fold reduction in T cell number in the spleen, pancreatic and inguinal lymph nodes

decreased CD4-positive, alpha-beta T cell number ( J:143620 )

• 2 fold reduction in CD4+ cells in the spleen, pancreatic and inguinal lymph nodes

• 8 fold increase in apoptotic cells in the spleen, pancreatic and inguinal lymph nodes

decreased CD8-positive, alpha-beta T cell number ( J:143620 )

• 20 fold reduction in CD8+ cells in the spleen, pancreatic and inguinal lymph nodes

• 4 fold increase in apoptotic cells in the spleen, pancreatic and inguinal lymph nodes

decreased NK T cell number ( J:143620 )

• numbers significantly reduced in bone marrow and the spleen

abnormal spleen morphology ( J:143620 )

• abnormalities in spleen morphology are less pronounced than those seen in the liver

spleen hypoplasia ( J:143620 )

• splenic cellularity reduced 2 fold

small lymph nodes ( J:143620 )

• pancreatic lymph nodes are small and grayish at 10-16 weeks of age

abnormal response to transplant ( J:143620 )

• bone marrow cells are deficient in repopulating lethally irradiated hosts

liver/biliary system

liver/biliary system phenotype ( J:143620 )

N • livers are normal at 2 weeks

hepatic necrosis ( J:143620 )

• hepatocellular degeneration and necrosis

abnormal liver development ( J:143620 )

• small foci of hematopoietic cells can be found at two weeks

• mononuclear and polymorphonuclear cells are abundant

• hematopoietic precursors are present, particularly those for granulocytes

abnormal liver parenchyma morphology ( J:143620 )

• parenchymal collapse

liver degeneration ( J:143620 )

• scarred, retracted, and hyperemic hepatic tissue

• hepatocellular degeneration and necrosis

pale liver ( J:143620 )

• livers develop pale nodules

cellular

hepatic necrosis ( J:143620 )

• hepatocellular degeneration and necrosis