|
Allele Symbol Allele Name Allele ID |
Scn8aClth cloth-ears MGI:3827095 |
| Summary |
4 genotypes |
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice exhibit normal vestibular function, no evidence of otitis media and normal cochlear hair cell morphology and function
|
|
• more so than in heterozygotes
|
|
• response to the click-box
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice exhibit a normal lifespan
|
|
• mice exhibit episodic periods of extended freezing behavior, piloerection, and a hunched posture unlike wild-type mice
• however, mice exhibit normal gait, limb strength, and vestibular-dependent behaviors
|
|
• anesthetized mice exhibit dystonic postures and a longer recovery time compared with wild-type mice
|
|
• at 5 to 6 months, mice exhibit increased latency to enter the light half of a light dark chamber compared with wild-type mice
• at 6 weeks, mice exhibit increase in the frequency of freezing in a clickbox test compared with wild-type mice
• at 10 weeks, mice exhibit increase in duration of freezing in a clickbox test compared with wild-type mice
• however, behavior in an open field is normal
|
|
• when suspended by their tails, mice exhibit trunk circling behavior unlike similarly treated wild-type mice
• beginning at 10 weeks, toe-pinch reflex is impaired compared to in wild-type mice
• however, mice exhibit normal corneal, pinna, and reaching reflexes
|
|
• mice exhibit decreased startle reflex compared with wild-type mice at greater penetrance than in homozygous mice that worsens with age
|
|
• as early as P8, mice exhibit continuous tremors that increase in severity with age and a dominant episodic tremor with behavioral arrest unlike wild-type mice
• tremors during freezing period are increased in severity and amplitude
|
|
• in a wire maneuver test
|
| N |
• outer, middle, and inner ears are morphologically normal
|
|
• the waveform of ABR is abnormal compared to controls
|
|
• between 8 and 26 kHz, mice exhibit increased auditory brainstem response (ABR) threshold compared with wild-type mice
|
|
• mild semi-dominant
|
|
• slightly
|
|
• slightly
|
|
• as early as 6 weeks
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice exhibit normal vestibular function, no evidence of otitis media and normal cochlear hair cell morphology and function
|
|
• mild to absent response to the click-box
|
|
• mild to absent response to the click-box
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• as early as P25, some mice exhibit episodic periods of extended freezing behavior, piloerection, a hunched posture, and intermittent side-to-side coarse tremors unlike wild-type mice
• however, mice exhibit normal vestibular-dependent behaviors
|
|
• Peyer's reflex is mild or absent unlike in wild-type mice
|
|
• in some mice
|
|
• at 5 weeks of age, startle reflex is mild or absent compared to in wild-type mice
• impaired startle reflex worsens with age
|
|
• mice exhibit episodic tremors that increase in frequency and severity with age unlike wild-type mice
|
| N |
• outer, middle, and inner ears are morphologically normal
|
|
• mild semi-dominant
|
|
• as early as 18 weeks
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 05/07/2024 MGI 6.23 |
|
|
|
||
Analysis Tools