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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Arg1tm1Pmu
targeted mutation 1, Peter J Murray
MGI:3826847
Summary 2 genotypes


Genotype
MGI:3826860
cn1
Allelic
Composition		 Arg1tm1Pmu/Arg1tm1Pmu
Lyz2tm1(cre)Ifo/?
Genetic
Background		 B6.Cg-Arg1tm1Pmu Lyz2tm1(cre)Ifo
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arg1tm1Pmu mutation (2 available); any Arg1 mutation (25 available)
Lyz2tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to parasitic infection ( J:143229 )
• mice are resistant to the wasting disease caused by systemic infection with T. gondii
• control mice lose 20% of their body weight by 40 days after T. gondii infection while infected mutant mice have no loss of body weight




Genotype
MGI:3826863
cn2
Allelic
Composition		 Arg1tm1Pmu/Arg1tm1Pmu
Tg(Tek-cre)1Ywa/?
Genetic
Background		 B6.Cg-Tg(Tek-cre)1Ywa Arg1tm1Pmu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arg1tm1Pmu mutation (2 available); any Arg1 mutation (25 available)
Tg(Tek-cre)1Ywa mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal macrophage physiology ( J:143229 )
• very little urea is produced by peritoneal macrophages in response to IL-4 and IL-10 incubation due to a lack of arginase activity
increased macrophage nitric oxide production ( J:143229 )
• macrophages produce more nitrous oxide in response to LPS stimulation or Mycobacterium bovis infection
decreased susceptibility to bacterial infection ( J:143229 )
• mice infected with M. tuberculosis have lower bacterial counts than wild-type littermates in the lungs after the initial bacterial growth period
• there is also lower bacterial load in the spleens of the mice 70 days after infection with M. tuberculosis
• lung granulomas in these infected mice occupy a smaller fraction of the total lung area and have a more pronounced lymphocytic infiltrate

homeostasis/metabolism
abnormal nitric oxide homeostasis ( J:143229 )
• there is more NO activity in liver granulomas of mice infected with M. tuberculosis
increased macrophage nitric oxide production ( J:143229 )
• macrophages produce more nitrous oxide in response to LPS stimulation or Mycobacterium bovis infection

hematopoietic system
abnormal macrophage physiology ( J:143229 )
• very little urea is produced by peritoneal macrophages in response to IL-4 and IL-10 incubation due to a lack of arginase activity
increased macrophage nitric oxide production ( J:143229 )
• macrophages produce more nitrous oxide in response to LPS stimulation or Mycobacterium bovis infection




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory