About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Igf1tm2Arge
targeted mutation 2, Argiris Efstratiadis
MGI:3821754
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Igf1tm2Arge/Igf1tm2Arge involves: 129S/SvEv * C57BL/6J MGI:3821760
ht2
 		Igf1tm2Arge/Igf1tm2.1Arge involves: 129S/SvEv * C57BL/6J * CBA MGI:3821764
cn3
 		Igf1tm2Arge/Igf1tm2Arge
Tg(SERPINA1-cre)1Arge/0 		involves: 129S/SvEv * C57BL/6J MGI:3821761
cn4
 		Igf1tm2Arge/Igf1tm2.1Arge
Tg(SERPINA1-cre)1Arge/0 		involves: 129S/SvEv * C57BL/6J * CBA MGI:3821763


Genotype
MGI:3821760
hm1
Allelic
Composition		 Igf1tm2Arge/Igf1tm2Arge
Genetic
Background		 involves: 129S/SvEv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1tm2Arge mutation (0 available); any Igf1 mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased survivor rate ( J:142247 )
• only 11% of neonates survive
neonatal lethality, incomplete penetrance ( J:142247 )
• only 11% of neonates survive

reproductive system

growth/size/body
decreased body weight ( J:142247 )
• mice weigh 34% of wild-type
postnatal growth retardation ( J:142247 )

homeostasis/metabolism
decreased circulating insulin-like growth factor I level ( J:142247 )
• at P72, IGF1 serum levels are below detectable levels

skeleton
abnormal long bone epiphyseal plate proliferative zone ( J:142247 )
• the proliferative zone is half the size of the hypertrophic zone unlike in wild-type mice
decreased long bone epiphyseal plate size ( J:142247 )
• the proliferative zone and hypertrophic zone of the tibia growth plates are decreased compared to in wild-type mice




Genotype
MGI:3821764
ht2
Allelic
Composition		 Igf1tm2Arge/Igf1tm2.1Arge
Genetic
Background		 involves: 129S/SvEv * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1tm2.1Arge mutation (0 available); any Igf1 mutation (27 available)
Igf1tm2Arge mutation (0 available); any Igf1 mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body weight ( J:142247 )
• mice weigh 54% of wild-type

homeostasis/metabolism
decreased circulating insulin-like growth factor I level ( J:142247 )
• at E18.5, IGF1 serum levels are 21% of normal
• at P72, IGF1 serum levels are 26% of normal




Genotype
MGI:3821761
cn3
Allelic
Composition		 Igf1tm2Arge/Igf1tm2Arge
Tg(SERPINA1-cre)1Arge/0
Genetic
Background		 involves: 129S/SvEv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1tm2Arge mutation (0 available); any Igf1 mutation (27 available)
Tg(SERPINA1-cre)1Arge mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased survivor rate ( J:142247 )
• only 11% of neonates survive
neonatal lethality, incomplete penetrance ( J:142247 )
• only 11% of neonates survive

reproductive system
reproductive system phenotype ( J:142247 )
N
• unlike Igf1tm2Arge homozygotes, mice are fertile

growth/size/body
decreased body weight ( J:142247 )
• mice weigh 50% of wild-type

homeostasis/metabolism
decreased circulating insulin-like growth factor I level ( J:142247 )
• at E18.5, IGF1 serum levels are below detectable levels
• at P72, IGF1 serum levels are 44% of normal




Genotype
MGI:3821763
cn4
Allelic
Composition		 Igf1tm2Arge/Igf1tm2.1Arge
Tg(SERPINA1-cre)1Arge/0
Genetic
Background		 involves: 129S/SvEv * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1tm2.1Arge mutation (0 available); any Igf1 mutation (27 available)
Igf1tm2Arge mutation (0 available); any Igf1 mutation (27 available)
Tg(SERPINA1-cre)1Arge mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body weight ( J:142247 )
• mice weigh 61% of wild-type

homeostasis/metabolism
decreased circulating insulin-like growth factor I level ( J:142247 )
• at E18.5, IGF1 serum levels are 24% of normal
• at P72, IGF1 serum levels are 60% of normal




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory