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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(tetO-Nfatct1*)1Grc
transgene insertion 1, Gerald R Crabtree
MGI:3820649
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Rag2tm1Fwa/Rag2tm1Fwa
Tg(EmuSR-tTa)83Bop/0
Tg(tetO-Nfatct1*)1Grc/0 		involves: 129S/SvEv * C57BL/6J * CBA/J * FVB/N MGI:3820654


Genotype
MGI:3820654
cx1
Allelic
Composition		 Rag2tm1Fwa/Rag2tm1Fwa
Tg(EmuSR-tTa)83Bop/0
Tg(tetO-Nfatct1*)1Grc/0
Genetic
Background		 involves: 129S/SvEv * C57BL/6J * CBA/J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag2tm1Fwa mutation (48 available); any Rag2 mutation (117 available)
Tg(EmuSR-tTa)83Bop mutation (1 available)
Tg(tetO-Nfatct1*)1Grc mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal double-positive T cell morphology ( J:141917 )
• 4 to 30% DP thymocytes appear allowing some DN cells to progress to the DP state, which is fewer than in wild-type mice but more than in Rag2 null mice

immune system
abnormal double-positive T cell morphology ( J:141917 )
• 4 to 30% DP thymocytes appear allowing some DN cells to progress to the DP state, which is fewer than in wild-type mice but more than in Rag2 null mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory