All Phenotypes Igf1r<tm1Jcbr> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Igf1r^tm1Jcbr
targeted mutation 1, Jens C Bruning
MGI:3818453

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Igf1r^tm1Jcbr/Igf1r^tm1Jcbr Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0	B6.Cg-Ndor1^{Tg(UBC-cre/ERT2)1Ejb} Igf1r^tm1Jcbr	MGI:5904250
cn2	Igf1r^tm1Jcbr/Igf1r^tm1Jcbr Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0	involves: 129S/SvEv * C57BL/6	MGI:5779542
cn3	Igf1r^tm1Jcbr/Igf1r^tm1Jcbr Tg(Scgb1a1-cre)1Tauc/0	involves: C57BL/6	MGI:5904182
cn4	Igf1r^tm1Jcbr/Igf1r^tm1Jcbr Tg(Nkx2-1-cre)2Sand/0	involves: C57BL/6	MGI:5904181
cn5	Igf1r^tm1Jcbr/Igf1r^tm1Jcbr Tg(Fabp4-cre)1Abel/?	involves: C57BL/6 * FVB/N	MGI:3818455

Allelic Composition	Igf1r^tm1Jcbr/Igf1r^tm1Jcbr Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0
Genetic Background	B6.Cg-Ndor1^{Tg(UBC-cre/ERT2)1Ejb} Igf1r^tm1Jcbr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1r^tm1Jcbr mutation (0 available); any Igf1r mutation (86 available)
Ndor1^{Tg(UBC-cre/ERT2)1Ejb} mutation (6 available); any Ndor1 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased susceptibility to type I hypersensitivity reaction ( J:241924 )

• mice challenged with house dust mite extract show improved lung function, attenuated airway hyperresponsiveness and mucus secretion, decrease in blood and bronchioalveolar lavage fluid eosinophils, a decrease in lung IL13 levels and collagen levels, decrease in smooth muscle thickness and depletion of goblet cell metaplasia compared to controls

mortality/aging

abnormal susceptibility to injury induced morbidity/mortality ( J:241920 )

• tamoxifen treated mice treated with bleomycin to induce lung damage at 6 weeks of age show increased survival (79%) compared to controls (33%)

homeostasis/metabolism

decreased collagen level ( J:241924 )

• house dust mite-induced increase in airway collagen content is reduced in tamoxifen treated mice

abnormal susceptibility to injury induced morbidity/mortality ( J:241920 )

• tamoxifen treated mice treated with bleomycin to induce lung damage at 6 weeks of age show increased survival (79%) compared to controls (33%)

decreased susceptibility to injury ( J:241920 )

• tamoxifen treated mice show protection against lung vascular fragility and permeability, reduced inflammatory cell presence in bronchioalveolar lavage fluid, reduced proliferation in lung perivascular areas and the alveolar parenchyma, reduced alveolar damage, and attenuation of acute lung inflammation and bone marrow neutrophilopoiesis after bleomycin-induced lung damage

respiratory system

decreased respiratory mucosa goblet cell number ( J:241924 )

• house dust mite-induced goblet cell hyperplasia is reduced in tamoxifen treated mice

decreased airway responsiveness ( J:241924 )

• house dust mite-induced airway hyperresponsiveness is attenuated in tamoxifen treated mice

Allelic Composition	Igf1r^tm1Jcbr/Igf1r^tm1Jcbr Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0
Genetic Background	involves: 129S/SvEv * C57BL/6

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♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:221618 )

N	• tamoxifen-treated mice exhibit normal testicular peritubular capsule and Leydig cells

small seminiferous tubules ( J:221618 )

• in tamoxifen-treated mice

decreased testis weight ( J:221618 )

• in mice treated with tamoxifen at 4 weeks

abnormal spermatogenesis ( J:221618 )

• in tamoxifen-treated mice

azoospermia ( J:221618 )

• in tamoxifen-treated mice

oligozoospermia ( J:221618 )

• seminiferous tubules in tamoxifen-treated mice are severely depleted of germ cells, including spermatogonia, spermatocytes, and spermatids

growth/size/body

decreased body weight ( J:221618 )

• beginning after a week tamoxifen treatment starting at 4 weeks

postnatal growth retardation ( J:221618 )

• in mice treated with tamoxifen at 4 weeks

respiratory system

abnormal bronchiole epithelium morphology ( J:221618 )

• distal bronchiolar epithelium in tamoxifen-treated mice is flatter with frequent interruptions and reduced cell height, proportion of cells with apical regions extruding into the bronchiolar lumen and nuclear density compared with control cells

abnormal pulmonary alveolar parenchyma morphology ( J:221618 )

• higher cellular density in tamoxifen-treated mice without a change in apoptosis rates

liver/biliary system

increased hepatocyte proliferation ( J:221618 )

• 2-3 times higher in tamoxifen-treated mice without an affect in liver cellularity density or changes in apoptosis rates compared with wild-type mice

cellular

azoospermia ( J:221618 )

• in tamoxifen-treated mice

oligozoospermia ( J:221618 )

• seminiferous tubules in tamoxifen-treated mice are severely depleted of germ cells, including spermatogonia, spermatocytes, and spermatids

increased hepatocyte proliferation ( J:221618 )

• 2-3 times higher in tamoxifen-treated mice without an affect in liver cellularity density or changes in apoptosis rates compared with wild-type mice

endocrine/exocrine glands

small seminiferous tubules ( J:221618 )

• in tamoxifen-treated mice

decreased testis weight ( J:221618 )

• in mice treated with tamoxifen at 4 weeks

Allelic Composition	Igf1r^tm1Jcbr/Igf1r^tm1Jcbr Tg(Scgb1a1-cre)1Tauc/0
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1r^tm1Jcbr mutation (0 available); any Igf1r mutation (86 available)
Tg(Scgb1a1-cre)1Tauc mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal response to injury ( J:241923 )

• mice show a mild delay in recovery of terminal bronchiolar epithelium after naphthalene treatment to induce club cell damage, with a delay in the differentiation/regeneration of club and ciliated cells

respiratory system

abnormal bronchiole epithelium morphology ( J:241923 )

• smaller epithelial cell size in some terminal bronchioles

• lower proportion of Scgb1a1+ club cells in some terminal bronchioles

Allelic Composition	Igf1r^tm1Jcbr/Igf1r^tm1Jcbr Tg(Nkx2-1-cre)2Sand/0
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1r^tm1Jcbr mutation (0 available); any Igf1r mutation (86 available)
Tg(Nkx2-1-cre)2Sand mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

increased body weight ( J:241923 )

• mice are significantly overweight after puberty

homeostasis/metabolism

abnormal response to injury ( J:241923 )

• mice show a delay in recovery of terminal bronchiolar epithelium after naphthalene treatment to induce club cell damage, with a delay in the differentiation/regeneration of club and ciliated cells

• mice show increased proliferation of bronchiolar epithelial cells during repair of the epithelium after naphthalene treatment to induce damage and club cell ablation

respiratory system

abnormal bronchiole epithelium morphology ( J:241923 )

• smaller epithelial cell size in terminal bronchioles

• lower proportion of Scgb1a1+ club cells

• distal bronchiolar epithelium shows morphological changes including lower cell density, flatter cells with elongated nuclei and frequent interruptions of normal columnar organization

• however, no gross morphological alterations are seen in AEC2 cells or in the surrounding alveolar parenchyma

• proliferation of airway club cells is enhanced in terminal bronchial epithelium

Allelic Composition	Igf1r^tm1Jcbr/Igf1r^tm1Jcbr Tg(Fabp4-cre)1Abel/?
Genetic Background	involves: C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1r^tm1Jcbr mutation (0 available); any Igf1r mutation (86 available)
Tg(Fabp4-cre)1Abel mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

increased heart weight ( J:141321 )

• disproportionately increased at 24 weeks

increased body weight ( J:141321 )

• both males and females have gained more weight than controls by 10 weeks of age

• daily food intake normal

increased body length ( J:141321 )

• significantly increased naso-anal length by 24-32 weeks of age

increased liver weight ( J:141321 )

• disproportionately increased at 24 weeks

adipose tissue

increased total body fat amount ( J:141321 )

• disproportionately increased in weight at 24 weeks

abnormal fat cell morphology ( J:141321 )

• increased number and diameter of adipocytes

increased fat cell size ( J:141321 )

abnormal gonadal fat pad morphology ( J:141321 )

• adipocyte abnormalities particularly evident in epigonadal fat

liver/biliary system

increased liver weight ( J:141321 )

• disproportionately increased at 24 weeks

cardiovascular system

increased heart weight ( J:141321 )

• disproportionately increased at 24 weeks

nervous system

decreased brain size ( J:141321 )

• relative brain weight is significantly reduced at 24 weeks

homeostasis/metabolism

abnormal glucose homeostasis ( J:141321 )

increased circulating glucose level ( J:141321 )

• fasted blood glucose significantly increased at 12 weeks but not 24 weeks of age

• fed blood glucose levels in males also increased at 12 weeks

increased insulin sensitivity ( J:141321 )

• of isolated adipocytes

decreased adiponectin level ( J:141321 )

• significantly lower at 12 weeks

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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