Phenotypes associated with this allele

• Allele Symbol: Hsd11b1^tm1.1Ggla
• Allele Name: targeted mutation 1.1, Gareth Lavery
• Allele ID: MGI:3817966
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hsd11b1^tm1.1Ggla/Hsd11b1^tm1.1Ggla	involves: 129P2/OlaHsd	MGI:4410479
hm2	Hsd11b1^tm1.1Ggla/Hsd11b1^tm1.1Ggla	involves: 129P2/OlaHsd * C57BL/6 * FVB/N	MGI:5444446
cx3	H6pd^tm1Pmst/H6pd^tm1Pmst Hsd11b1^tm1.1Ggla/Hsd11b1^tm1.1Ggla	involves: 129P2/OlaHsd * C57BL/6 * FVB/N	MGI:5444447

Genotype
MGI:4410479

hm1

• Allelic Composition: Hsd11b1^tm1.1Ggla/Hsd11b1^tm1.1Ggla
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased circulating corticosterone level ( J:189059 )

• greater than in conditional knock-out mice

abnormal enzyme/coenzyme activity ( J:141273 )

• microsomes from liver, adipose tissue, or muscles lack oxo-reductase or dehydrogenase activity compared to in wild-type microsomes

decreased liver enzyme/coenzyme activity ( J:189059 )

• microsomes from liver lack oxo-reductase or dehydrogenase activity compared to in wild-type microsomes

decreased muscle enzyme/coenzyme activity ( J:189059 )

• microsomes from muscles lack oxo-reductase or dehydrogenase activity compared to in wild-type microsomes

endocrine/exocrine glands

enlarged adrenal glands ( J:189059 )

• greater than in conditional knock-out mice

muscle

decreased muscle enzyme/coenzyme activity ( J:189059 )

• microsomes from muscles lack oxo-reductase or dehydrogenase activity compared to in wild-type microsomes

liver/biliary system

decreased liver enzyme/coenzyme activity ( J:189059 )

• microsomes from liver lack oxo-reductase or dehydrogenase activity compared to in wild-type microsomes

Genotype
MGI:5444446

hm2

• Allelic Composition: Hsd11b1^tm1.1Ggla/Hsd11b1^tm1.1Ggla
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

endocrine/exocrine glands

enlarged adrenal glands ( J:189132 )

• increased adrenal weight

muscle

muscle phenotype ( J:189132 )

N • mice do not exhibit abnormal skeletal muscle morphology

Genotype
MGI:5444447

cx3

• Allelic Composition: H6pd^tm1Pmst/H6pd^tm1Pmst; Hsd11b1^tm1.1Ggla/Hsd11b1^tm1.1Ggla
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

muscle

increased skeletal muscle glycogen level ( J:189132 )

• in some fibers

decreased quadriceps weight ( J:189132 )

• at 10 weeks

decreased tibialis anterior weight ( J:189132 )

• at 10 weeks

abnormal skeletal muscle fiber morphology ( J:189132 )

• vacuolated type fibers in quadriceps and tibialis anterior muscle

centrally nucleated skeletal muscle fibers ( J:189132 )

• in quadriceps and tibialis anterior muscle

skeletal muscle atrophy ( J:189132 )

• of the quadriceps and tibialis anterior muscle

growth/size/body

decreased lean body mass ( J:189132 )

• at 10 weeks, mice exhibit a decrease in quadriceps and tibialis anterior muscle compared with control mice

decreased body weight ( J:189132 )

• at 10 weeks

homeostasis/metabolism

decreased circulating glucose level ( J:189132 )

• in fasted mice

increased skeletal muscle glycogen level ( J:189132 )

• in some fibers

endocrine/exocrine glands

enlarged adrenal glands ( J:189132 )

• increased adrenal weight

limbs/digits/tail

decreased quadriceps weight ( J:189132 )

• at 10 weeks

decreased tibialis anterior weight ( J:189132 )

• at 10 weeks