Hsd11b1tm1.1Ggla
Targeted Allele Detail
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Symbol: |
Hsd11b1tm1.1Ggla |
Name: |
hydroxysteroid 11-beta dehydrogenase 1; targeted mutation 1.1, Gareth Lavery |
MGI ID: |
MGI:3817966 |
Gene: |
Hsd11b1 Location: Chr1:192903948-192946353 bp, - strand Genetic Position: Chr1, 97.67 cM
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Alliance: |
Hsd11b1tm1.1Ggla page
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Germline Transmission: |
Earliest citation of germline transmission:
J:141273
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Parent Cell Line: |
E14TG2a (ES Cell)
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Strain of Origin: |
129P2/OlaHsd
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A floxed neo cassette was inserted upstream of exon 5. An additional loxP site was inserted downstream of exon 5. Cre-mediated recombination removed the neo cassette and exon 5. RT-PCR confirmed the absence of transcript expression in the liver, tibialis anterior amd soleus. The absence of enzymatic activity was confirmed.
(J:189132)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Hsd11b1 Mutation: |
27 strains or lines available
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Original: |
J:141273 Swali A, et al., 11beta-Hydroxysteroid dehydrogenase type 1 regulates insulin and glucagon secretion in pancreatic islets. Diabetologia. 2008 Nov;51(11):2003-11 |
All: |
18 reference(s) |
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