Phenotypes associated with this allele

• Allele Symbol: Raf1^tm3Ulb
• Allele Name: targeted mutation 3, Catrin Pritchard
• Allele ID: MGI:3817448
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Raf1^tm3Ulb/Raf1^tm3Ulb	Not Specified	MGI:3817449

Genotype
MGI:3817449

hm1

• Allelic Composition: Raf1^tm3Ulb/Raf1^tm3Ulb
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:141095 )

• die between E10.5 and E12.5

embryo

increased embryonic tissue cell apoptosis ( J:141095 )

• widespread apoptosis in embryos

embryonic growth retardation ( J:141095 )

cellular

increased sensitivity to induced cell death ( J:141095 )

• increase in apoptosis in MEFs in response to serum withdrawal, etpposide, and alpha-CD95 antibody

increased embryonic tissue cell apoptosis ( J:141095 )

• widespread apoptosis in embryos

decreased cell proliferation ( J:141095 )

• MEFs have a reduced capacity to grow

growth/size/body

embryonic growth retardation ( J:141095 )