Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sting1tm1Gnb mutation
(0 available);
any
Sting1 mutation
(49 available)
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immune system
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• macrophages exhibit a modest decrease in response to Sendai virus compared with wild-type cells
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sting1tm1Gnb mutation
(0 available);
any
Sting1 mutation
(49 available)
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immune system
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• mouse embryonic fibroblasts (MEF) are defective in initiating immune defenses (i.e. interferon-beta induction ) in response to negative strand viruses such as vesicular stomatitis virus (VSV) and the Sendai virus or the DNA herpes simplex virus 1
• b-form DNA, interferon stimulatory DNA, and the bacteria Listeria monocytogenes also fail to elicit a response in mutant MEFs
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• MEFs produce less interferon-beta in response to herpes simplex-1 virus
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• MEFs infected with vesicular stomatitis virus (VSV) have 100-fold higher titer number than controls 24 to 36 hours after infection
• MEFs produce less interferon-beta in response to VSV and the Sendai viruses
• less susceptibility to VSV is observed in bone marrow-derived dendritic cells or macrophages
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rnaseh2atm1Crh mutation
(0 available);
any
Rnaseh2a mutation
(45 available)
Sting1tm1Gnb mutation
(0 available);
any
Sting1 mutation
(49 available)
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mortality/aging
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• mice are either perinatal lethal or survive after birth; survival is at 6% of expected frequency with 2% of pups surviving weaning
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growth/size/body
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• surviving mice are about 70% in body size and weight compared to controls
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• surviving mice are about 70% in body size and weight compared to controls
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pigmentation
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• white patches show lack of melanin in hair shafts
• however, skin histology from white patches in normal
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• all viable mice present a ventral white spotting phenotype and white hind- and forepaws from birth which remains through life
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cellular
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• E13.5 and E15.5 embryos exhibit increased LINE-1 retroelement DNA levels in cytosolic extract, however, no elevation in L1 ORF1 protein is seen
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integument
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• however, skin histology from white patches in normal
• white patches show lack of melanin in hair shafts
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• all viable mice present a ventral white spotting phenotype and white hind- and forepaws from birth which remains through life
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reproductive system
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• mice fail to produce offspring
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immune system
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N |
• no abnormalities or inflammation in internal organs, including the brain, are seen in viable mice and expression of interferon-stimulated genes is restored to normal levels
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sting1tm1Gnb mutation
(0 available);
any
Sting1 mutation
(49 available)
Trex1tm1Tld mutation
(2 available);
any
Trex1 mutation
(22 available)
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mortality/aging
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N |
• mice exhibit normal survival unlike Trex1tm1Tld homozygotes
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immune system
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N |
• mice do not exhibit multi-organ inflammation unlike Trex1tm1Tld homozygotes
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Analysis Tools
