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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dlg1tm1Rlh
targeted mutation 1, Richard L Huganir
MGI:3817231
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Dlg1tm1Rlh/Dlg1tm1Rlh
Tg(CMV-cre)1Nagy/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3817233
cn2
 		Dlg1tm1Rlh/Dlg1tm1Rlh
Mnx1tm4(cre)Tmj/Mnx1+ 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3817234
cn3
 		Dlg1tm1Rlh/Dlg1tm1Rlh
Tg(Cd4-cre)1Cwi/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2 MGI:5464885
cn4
 		Dlg1tm1Rlh/Dlg1tm1Rlh
Tg(Mpz-cre)26Mes/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/NTac MGI:5558043
cn5
 		Dlg1tm1Rlh/Dlg1tm1.1Rlh
Tg(Mpz-cre)26Mes/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/NTac MGI:5558044


Genotype
MGI:3817233
cn1
Allelic
Composition		 Dlg1tm1Rlh/Dlg1tm1Rlh
Tg(CMV-cre)1Nagy/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dlg1tm1Rlh mutation (1 available); any Dlg1 mutation (75 available)
Tg(CMV-cre)1Nagy mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality ( J:141127 )
• mice exhibit the same early lethality as in Dlg1Gt(gt1.8geo)1Ber homozygotes

craniofacial
abnormal craniofacial morphology ( J:141127 )
• mice exhibit the same craniofacial defects as in Dlg1Gt(gt1.8geo)1Ber homozygotes




Genotype
MGI:3817234
cn2
Allelic
Composition		 Dlg1tm1Rlh/Dlg1tm1Rlh
Mnx1tm4(cre)Tmj/Mnx1+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dlg1tm1Rlh mutation (1 available); any Dlg1 mutation (75 available)
Mnx1tm4(cre)Tmj mutation (2 available); any Mnx1 mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal dendrite morphology ( J:141127 )
• mice exhibit an 80% decrease in dendrite branches, a 50% reduction in overall tree size, a 50% reduction in average dendrite length and a 15% reduction in the length of the longest dendrite compared to in wild-type mice




Genotype
MGI:5464885
cn3
Allelic
Composition		 Dlg1tm1Rlh/Dlg1tm1Rlh
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dlg1tm1Rlh mutation (1 available); any Dlg1 mutation (75 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal CD4-positive, alpha-beta T cell physiology ( J:191788 )
• T cells exhibit an increase in migration towards CCL19 compared with control cells
abnormal T-helper 1 physiology ( J:191788 )
• CD4+ T cells re-stimulated with anti-CD3 exhibit decreased production of Th1-associated cytokines compared with control cells
abnormal T-helper 2 physiology ( J:191788 )
• CD4+ T cells re-stimulated with anti-CD3 exhibit increased production of Th2-associated cytokines compared with control cells
decreased interferon-gamma secretion ( J:191788 )
• in CD4+ T cells re-stimulated with anti-CD3
decreased interleukin-2 secretion ( J:191788 )
• in CD4+ T cells re-stimulated with anti-CD3
increased interleukin-4 secretion ( J:191788 )
• in CD4+ T cells re-stimulated with anti-CD3
increased interleukin-5 secretion ( J:191788 )
• in CD4+ T cells re-stimulated with anti-CD3
decreased tumor necrosis factor secretion ( J:191788 )
• in CD4+ T cells re-stimulated with anti-CD3

hematopoietic system
abnormal CD4-positive, alpha-beta T cell physiology ( J:191788 )
• T cells exhibit an increase in migration towards CCL19 compared with control cells
abnormal T-helper 1 physiology ( J:191788 )
• CD4+ T cells re-stimulated with anti-CD3 exhibit decreased production of Th1-associated cytokines compared with control cells
abnormal T-helper 2 physiology ( J:191788 )
• CD4+ T cells re-stimulated with anti-CD3 exhibit increased production of Th2-associated cytokines compared with control cells




Genotype
MGI:5558043
cn4
Allelic
Composition		 Dlg1tm1Rlh/Dlg1tm1Rlh
Tg(Mpz-cre)26Mes/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dlg1tm1Rlh mutation (1 available); any Dlg1 mutation (75 available)
Tg(Mpz-cre)26Mes mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
hypermyelination ( J:202688 )
• at P10, P20 and P45
• however, myelination is normal at P90 and 6 months




Genotype
MGI:5558044
cn5
Allelic
Composition		 Dlg1tm1Rlh/Dlg1tm1.1Rlh
Tg(Mpz-cre)26Mes/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dlg1tm1.1Rlh mutation (0 available); any Dlg1 mutation (75 available)
Dlg1tm1Rlh mutation (1 available); any Dlg1 mutation (75 available)
Tg(Mpz-cre)26Mes mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:202688 )
N
• mice exhibit normal myelination at P90




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory