All Phenotypes Tg(Foxn1-cre)1Tbo MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ctnnb1^tm2Kem/Ctnnb1^tm2.1Kem Gt(ROSA)26Sor^{tm1(Ctnnb1)Kem}/Gt(ROSA)26Sor⁺ Tg(Foxn1-cre)1Tbo/0	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6	MGI:5440185
cn2	Ctnnb1^tm2Kem/Ctnnb1^tm2.1Kem Gt(ROSA)26Sor^{tm1(Ctnnb1)Kem}/Gt(ROSA)26Sor^{tm1(Ctnnb1)Kem} Tg(Foxn1-cre)1Tbo/0	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6	MGI:5440184
cn3	Ctnnb1^tm2Kem/Ctnnb1^tm2.1Kem Tg(Foxn1-cre)1Tbo/0	involves: 129S1/Sv * 129X1/SvJ	MGI:5440186
cn4	Cbx4^tm1.1Gxu/Cbx4^tm1.2Gxu Tg(Foxn1-cre)1Tbo/0	involves: 129S2/SvPas * C57BL/6J	MGI:5489934
cn5	Wls^tm1.1Arte/Wls^tm1.1Arte Tg(Foxn1-cre)1Tbo/0	involves: C57BL/6	MGI:5547812

Allelic Composition	Ctnnb1^tm2Kem/Ctnnb1^tm2.1Kem Gt(ROSA)26Sor^{tm1(Ctnnb1)Kem}/Gt(ROSA)26Sor⁺ Tg(Foxn1-cre)1Tbo/0
Genetic Background	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1^tm2.1Kem mutation (0 available); any Ctnnb1 mutation (49 available)
Ctnnb1^tm2Kem mutation (1 available); any Ctnnb1 mutation (49 available)
Gt(ROSA)26Sor^{tm1(Ctnnb1)Kem} mutation (0 available); any Gt(ROSA)26Sor mutation (944 available)
Tg(Foxn1-cre)1Tbo mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

integument phenotype ( J:187739 )

N	• skin lesions are not seen unlike in mutant mice lacking Gt(ROSA)26Sor^{tm1(Ctnnb1)Kem}

focal hair loss ( J:187739 )

• broad stripes of hair loss are seen

• loss is followed by regrowth

growth/size/body

decreased body size ( J:187739 )

• at P14; however, mice catch up with littermate controls with age

Allelic Composition	Ctnnb1^tm2Kem/Ctnnb1^tm2.1Kem Gt(ROSA)26Sor^{tm1(Ctnnb1)Kem}/Gt(ROSA)26Sor^{tm1(Ctnnb1)Kem} Tg(Foxn1-cre)1Tbo/0
Genetic Background	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

integument phenotype ( J:187739 )

N	• skin lesions are not seen unlike in mutant mice lacking Gt(ROSA)26Sor^{tm1(Ctnnb1)Kem}

sparse hair ( J:187739 )

• thinner but continuous coat

growth/size/body

decreased body size ( J:187739 )

• at P14; however, mice catch up with littermate controls with age

Allelic Composition	Ctnnb1^tm2Kem/Ctnnb1^tm2.1Kem Tg(Foxn1-cre)1Tbo/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:187739 )

• due to skin lesions

integument

skin lesions ( J:187739 )

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal thymus development ( J:194053 )

• expression analysis indicates a defect in the maturation of both medullary and cortical epithelial cells

thymus atrophy ( J:194053 )

• limited thymic epithelial architecture quickly deteriorates in postnatal mice with discrete cortical and medullary structures no longer seen at 3 weeks of age

thymus hypoplasia ( J:194053 )

• severe

abnormal thymus physiology ( J:194053 )

• expression analysis indicates impaired proliferation of developing epithelial cells

abnormal lymphopoiesis ( J:194053 )

• the double negative population is over-represented and composed primarily of B220+ B lineage cells instead of T lineage precursors

• however, the absolute number of B lineage cells in the thymus is similar to controls

decreased T cell number ( J:194053 )

• the T cell compartment in the periphery is never fully established in adult mice

• the CD3+ population in the spleen is small

decreased double-positive T cell number ( J:194053 )

• markedly reduced in proportion in the thymus at 3 weeks of age

• barely detectable at 6 weeks of age

immune system

abnormal thymus development ( J:194053 )

• expression analysis indicates a defect in the maturation of both medullary and cortical epithelial cells

thymus atrophy ( J:194053 )

• limited thymic epithelial architecture quickly deteriorates in postnatal mice with discrete cortical and medullary structures no longer seen at 3 weeks of age

thymus hypoplasia ( J:194053 )

• severe

abnormal thymus physiology ( J:194053 )

• expression analysis indicates impaired proliferation of developing epithelial cells

abnormal lymphopoiesis ( J:194053 )

• the double negative population is over-represented and composed primarily of B220+ B lineage cells instead of T lineage precursors

• however, the absolute number of B lineage cells in the thymus is similar to controls

decreased double-positive T cell number ( J:194053 )

• markedly reduced in proportion in the thymus at 3 weeks of age

• barely detectable at 6 weeks of age

decreased T cell number ( J:194053 )

• the T cell compartment in the periphery is never fully established in adult mice

• the CD3+ population in the spleen is small

endocrine/exocrine glands

abnormal thymus development ( J:194053 )

• expression analysis indicates a defect in the maturation of both medullary and cortical epithelial cells

thymus atrophy ( J:194053 )

• limited thymic epithelial architecture quickly deteriorates in postnatal mice with discrete cortical and medullary structures no longer seen at 3 weeks of age

thymus hypoplasia ( J:194053 )

• severe

abnormal thymus physiology ( J:194053 )

• expression analysis indicates impaired proliferation of developing epithelial cells

Allelic Composition	Wls^tm1.1Arte/Wls^tm1.1Arte Tg(Foxn1-cre)1Tbo/0
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Foxn1-cre)1Tbo mutation (0 available)
Wls^tm1.1Arte mutation (0 available); any Wls mutation (38 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

integument phenotype ( J:202499 )

N	• mice do not develop skin inflammation

sparse hair ( J:202499 )

• slightly less dense hair

immune system

immune system phenotype ( J:202499 )

N	• mice do not develop skin inflammation

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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