Phenotypes associated with this allele

• Allele Symbol: Tnk1^tm1Sksuf
• Allele Name: targeted mutation 1, W Stratford May
• Allele ID: MGI:3814727
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tnk1^tm1Sksuf/Tnk1^tm1Sksuf	involves: 129X1/SvJ * C57BL/6	MGI:3814730
ht2	Tnk1^tm1Sksuf/Tnk1^+	involves: 129X1/SvJ * C57BL/6	MGI:3814731

Genotype
MGI:3814730

hm1

• Allelic Composition: Tnk1^tm1Sksuf/Tnk1^tm1Sksuf
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased tumor incidence ( J:140639 )

• 43% (12 of 28) of mice develop spontaneous tumors with an average tumor latency of 17 months

• about 50% of mice synchronously developed more than 1 primary neoplasm

increased gastrointestinal tumor incidence ( J:140639 )

• the majority of tumors occur in the gastrointestinal tract

increased skin tumor incidence ( J:140639 )

• mice may also develop epithelial tumors of the skin

increased trichoepithelioma incidence ( J:140639 )

increased hepatocellular carcinoma incidence ( J:140639 )

increased lymphoma incidence ( J:140639 )

• 75% of mice with tumors had lymphoid tumors

increased B cell derived lymphoma incidence ( J:140639 )

• 7 of 28 mice developed malignant lymphomas of the small intestine and mesenteric lymph nodes

• lymphomas also developed in the spleen, thymus, salivary glands, and pancreas

• histologically lymphomas resembled lymphoblastic lymphomas

increased lung adenocarcinoma incidence ( J:140639 )

• mice may also develop lung adenocarcinomas

increased hemangiosarcoma incidence ( J:140639 )

• of the spleen

integument

increased skin tumor incidence ( J:140639 )

• mice may also develop epithelial tumors of the skin

increased trichoepithelioma incidence ( J:140639 )

digestive/alimentary system

increased gastrointestinal tumor incidence ( J:140639 )

• the majority of tumors occur in the gastrointestinal tract

respiratory system

increased lung adenocarcinoma incidence ( J:140639 )

• mice may also develop lung adenocarcinomas

liver/biliary system

increased hepatocellular carcinoma incidence ( J:140639 )

Genotype
MGI:3814731

ht2

• Allelic Composition: Tnk1^tm1Sksuf/Tnk1⁺
• Genetic Background: involves: 129X1/SvJ * C57BL/6

neoplasm

increased tumor incidence ( J:140639 )

• 27% (14 of 52) of mice develop spontaneous tumors

• most (72%) tumors are of an epithelial origin

• about 25% of mice synchronously developed more than 1 primary neoplasm

increased intestinal adenoma incidence ( J:140639 )

• 9 mice had lung or intestinal adenomas

increased pancreas tumor incidence ( J:140639 )

increased skin tumor incidence ( J:140639 )

• benign skin tumors form

increased trichoepithelioma incidence ( J:140639 )

increased hepatoma incidence ( J:140639 )

increased lung adenoma incidence ( J:140639 )

• 9 mice had lung or intestinal adenomas

increased lymphoma incidence ( J:140639 )

• in 28% of mice with tumors lymphomas of the spleen, pancreas, small intestine, and/or mesenteric lymph nodes are seen

increased malignant tumor incidence ( J:140639 )

• develop malignant tumors with age

increased carcinoma incidence ( J:140639 )

• pancreatic carcinoma

increased intestinal adenocarcinoma incidence ( J:140639 )

• small intestinal adenocarcinoma

increased hepatocellular carcinoma incidence ( J:140639 )

digestive/alimentary system

increased intestinal adenocarcinoma incidence ( J:140639 )

• small intestinal adenocarcinoma

increased intestinal adenoma incidence ( J:140639 )

• 9 mice had lung or intestinal adenomas

endocrine/exocrine glands

pancreatic islet hyperplasia ( J:140639 )

• seen in 30% of mice

• but only 1 mouse had a pancreatic islet tumor

increased pancreas tumor incidence ( J:140639 )

liver/biliary system

increased hepatocellular carcinoma incidence ( J:140639 )

increased hepatoma incidence ( J:140639 )

integument

increased skin tumor incidence ( J:140639 )

• benign skin tumors form

increased trichoepithelioma incidence ( J:140639 )

respiratory system

increased lung adenoma incidence ( J:140639 )

• 9 mice had lung or intestinal adenomas