Tnk1^tm1Sksuf
Targeted Allele Detail

Summary

• Symbol: Tnk1^tm1Sksuf
• Name: tyrosine kinase, non-receptor, 1; targeted mutation 1, W Stratford May
• MGI ID: MGI:3814727
• Synonyms: Tnk1^tm1Wsmay
• Gene: Tnk1 Location: Chr11:69741831-69749556 bp, - strand Genetic Position: Chr11, 42.9 cM
• Alliance: Tnk1^tm1Sksuf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:140639
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic region including exons 4 - 8 was replaced with a PGK-neo cassette via homologous recombination. Western blot analysis of liver extracts and MEFs confirms the absence of expression of the short isoform. (J:140639)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tnk1^tm1Sksuf

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tnk1 Mutation: 35 strains or lines available

References

• Original: J:140639 Hoare S, et al., Tnk1/Kos1 knockout mice develop spontaneous tumors. Cancer Res. 2008 Nov 1;68(21):8723-32
• All: 2 reference(s)