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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hspa5tm1Alee
targeted mutation 1, Amy S Lee
MGI:3814698
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Hspa5tm1Alee/Hspa5tm1Alee involves: 129 * C57BL/6 MGI:3814704
cn2
 		Hspa5tm1Alee/Hspa5tm1Alee
Ptentm1Hwu/Ptentm1Hwu
Tg(Pbsn-cre)4Prb/? 		involves: 129 * 129S4/SvJae * C57BL/6 * DBA/2 MGI:4943513
cn3
 		Hspa5tm1Alee/Hspa5+
Ptentm1Hwu/Ptentm1Hwu
Tg(Pbsn-cre)4Prb/? 		involves: 129 * 129S4/SvJae * C57BL/6 * DBA/2 MGI:4943514
cn4
 		Hspa5tm1Alee/Hspa5tm1.1Alee
Ptentm1Hwu/Ptentm1Hwu
Tg(Pbsn-cre)4Prb/? 		involves: 129 * 129S4/SvJae * C57BL/6 * DBA/2 MGI:4943512
cn5
 		Hspa5tm1Alee/Hspa5tm1Alee
Tg(Pbsn-cre)4Prb/0 		involves: 129 * C57BL/6 * DBA/2 MGI:4943515


Genotype
MGI:3814704
hm1
Allelic
Composition		 Hspa5tm1Alee/Hspa5tm1Alee
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hspa5tm1Alee mutation (0 available); any Hspa5 mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype




Genotype
MGI:4943513
cn2
Allelic
Composition		 Hspa5tm1Alee/Hspa5tm1Alee
Ptentm1Hwu/Ptentm1Hwu
Tg(Pbsn-cre)4Prb/?
Genetic
Background		 involves: 129 * 129S4/SvJae * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hspa5tm1Alee mutation (0 available); any Hspa5 mutation (38 available)
Ptentm1Hwu mutation (16 available); any Pten mutation (81 available)
Tg(Pbsn-cre)4Prb mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
neoplasm ( J:142106 )
N
• mice do not develop detectable cancerous or precancerous lesions in the prostate




Genotype
MGI:4943514
cn3
Allelic
Composition		 Hspa5tm1Alee/Hspa5+
Ptentm1Hwu/Ptentm1Hwu
Tg(Pbsn-cre)4Prb/?
Genetic
Background		 involves: 129 * 129S4/SvJae * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hspa5tm1Alee mutation (0 available); any Hspa5 mutation (38 available)
Ptentm1Hwu mutation (16 available); any Pten mutation (81 available)
Tg(Pbsn-cre)4Prb mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased prostate gland adenocarcinoma incidence ( J:142106 )
• mutants exhibit visible solid tumor mass with invasive adenocarcinoma in the anterior prostate, while the dorsolateral prostate and ventral prostate lobes keep their ductual structure, albeit with enlarged ducts
increased prostate intraepithelial neoplasia incidence ( J:142106 )
• dorsolateral prostate and ventral prostate exhibit diffusive prostate intraepithelial neoplasia (PIN) with intact basement membrane

endocrine/exocrine glands
increased prostate gland adenocarcinoma incidence ( J:142106 )
• mutants exhibit visible solid tumor mass with invasive adenocarcinoma in the anterior prostate, while the dorsolateral prostate and ventral prostate lobes keep their ductual structure, albeit with enlarged ducts
increased prostate intraepithelial neoplasia incidence ( J:142106 )
• dorsolateral prostate and ventral prostate exhibit diffusive prostate intraepithelial neoplasia (PIN) with intact basement membrane

reproductive system
increased prostate gland adenocarcinoma incidence ( J:142106 )
• mutants exhibit visible solid tumor mass with invasive adenocarcinoma in the anterior prostate, while the dorsolateral prostate and ventral prostate lobes keep their ductual structure, albeit with enlarged ducts
increased prostate intraepithelial neoplasia incidence ( J:142106 )
• dorsolateral prostate and ventral prostate exhibit diffusive prostate intraepithelial neoplasia (PIN) with intact basement membrane




Genotype
MGI:4943512
cn4
Allelic
Composition		 Hspa5tm1Alee/Hspa5tm1.1Alee
Ptentm1Hwu/Ptentm1Hwu
Tg(Pbsn-cre)4Prb/?
Genetic
Background		 involves: 129 * 129S4/SvJae * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hspa5tm1.1Alee mutation (1 available); any Hspa5 mutation (38 available)
Hspa5tm1Alee mutation (0 available); any Hspa5 mutation (38 available)
Ptentm1Hwu mutation (16 available); any Pten mutation (81 available)
Tg(Pbsn-cre)4Prb mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
neoplasm ( J:142106 )
N
• mice do not develop detectable cancerous or precancerous lesions in the prostate




Genotype
MGI:4943515
cn5
Allelic
Composition		 Hspa5tm1Alee/Hspa5tm1Alee
Tg(Pbsn-cre)4Prb/0
Genetic
Background		 involves: 129 * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hspa5tm1Alee mutation (0 available); any Hspa5 mutation (38 available)
Tg(Pbsn-cre)4Prb mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:142106 )
N
• mice are phenotypically normal and fertile and prostate morphology is normal




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory