Phenotypes associated with this allele
Allelic Composition |
Krastm5Tyj/Kras+
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Genetic Background |
involves: 129S4/SvJae * C57BL/6 |
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm5Tyj mutation
(2 available);
any
Kras mutation
(76 available)
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neoplasm
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• following administration of a flp-expressing adenovirus or lentivirus
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respiratory system
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• following administration of a flp-expressing adenovirus or lentivirus
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neoplasm
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• mice treated with flp-expressing adenovirus and tamoxifen on the same day exhibit sarcomas
• however, delayed tamoxifen-treatment reduces sarcoma formation
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mortality/aging
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• mice exhibit a decrease in median survival time which is approximately 4.5 months of age
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neoplasm
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• mice develop invasive pancreatic ductal adenocarcinoma
• however, mice show negligible metastasis to distant organs with only 2 mice showing liver metastasis
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• both low and high grade PanIN lesions are seen at 2-3 months of age, but by 6 months, invasive carcinoma is present
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endocrine/exocrine glands
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• mice develop invasive pancreatic ductal adenocarcinoma
• however, mice show negligible metastasis to distant organs with only 2 mice showing liver metastasis
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• both low and high grade PanIN lesions are seen at 2-3 months of age, but by 6 months, invasive carcinoma is present
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mortality/aging
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• mice exhibit a decrease in median survival time which is approximately 2 months of age
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neoplasm
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• mice develop invasive pancreatic ductal adenocarcinoma
• however, mice show negligible metastasis to distant organs
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• mice develop classical PanIN lesions that progress to invasive carcinoma
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endocrine/exocrine glands
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• mice develop invasive pancreatic ductal adenocarcinoma
• however, mice show negligible metastasis to distant organs
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• mice develop classical PanIN lesions that progress to invasive carcinoma
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neoplasm
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• lung tumors from mice injected with cre- and flpo-expressing adenoviruses exhibit a doubling time of 2 weeks
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• high-grade ling adenocarcinomas as early as 8 weeks after injection with cre- and flpo-expressing adenoviruses
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• extremity sarcomas as early as 8 weeks after injection with cre- and flpo-expressing adenoviruses
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respiratory system
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• high-grade ling adenocarcinomas as early as 8 weeks after injection with cre- and flpo-expressing adenoviruses
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