Trp53^tm1.1Dgk
Targeted Allele Detail

Summary

• Symbol: Trp53^tm1.1Dgk
• Name: transformation related protein 53; targeted mutation 1.1, David G Kirsch
• MGI ID: MGI:5306612
• Synonyms: p53^FRT
• Gene: Trp53 Location: Chr11:69471185-69482699 bp, + strand Genetic Position: Chr11, 42.83 cM, cytoband B2-C
• Alliance: Trp53^tm1.1Dgk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:180576
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to insert a FRT site upstream of exon 2, and a loxP-flanked neomycin resistance (neo) cassette followed by a second FRT site downstream of exon 6. Cre-mediated recombination removed the neo cassette. (J:180576)

Disease models

Tumor Data

List all tumor models in MMHCdb carrying Trp53^tm1.1Dgk

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Trp53 Mutation: 232 strains or lines available

References

• Original: J:180576 Lee CL, et al., Generation of primary tumors with Flp recombinase in FRT-flanked p53 mice. Dis Model Mech. 2012 May;5(3):397-402
• All: 29 reference(s)