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Allele Symbol Allele Name Allele ID |
Dlx3tm3Mso targeted mutation 3, Maria I Morasso MGI:3813133 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at P15 and P18
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• at P15 and P18
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• at P12, mice exhibit defects in the hair shaft
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• beginning at P5, mice exhibit abnormal hair follicles
• hair follicles undergo epidermalization unlike in wild-type mice
• at P12, mice exhibit defects in the inner root sheath with continued proliferation of outer root sheath cells in catagen and telogen unlike in wild-type mice
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• at P9, follicles have not develop hair bulbs and exhibit abnormal undifferentiated shafts with no keratinized medulla unlike in wild-type mice
• at P18, mice fail to exhibit upward movement of the hair shaft and formation of the club structure in the upper hair bulb as in wild-type mice
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• by telogen phase P20, hair follicles undergo regression and fail to re-initiate the hair cycle as in wild type mice
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• at P15, P18 and P26, proliferation of hair follicle cells is increased compared to in wild-type mice
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• the dermis is thickened and hypercellular compared to in wild-type mice
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• at P15 and P18, utricles develop in the epidermis unlike in wild-type mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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