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Allele Symbol Allele Name Allele ID |
Dsc3tm2Pko targeted mutation 2, Peter J Koch MGI:3812225 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• keratinocytes exhibit weak cell adhesion with only half-desmosomes forming on the bottom and roof of the blisters
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• mice exhibit empty cysts in the epidermis following loss of telogen club hairs
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• while some mice die shortly after birth, mice that do not exhibit obvious skin lesions develop to adulthood
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• mice that develop macroscopic skin blistering usually die within hours of birth
• however, mice that do not exhibit obvious skin lesions develop to adulthood
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| N |
• despite severe blistering, keratinocyte differentiation is normal
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• keratinocytes exhibit weak cell adhesion with only half-desmosomes forming on the bottom and roof of the blisters
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• mice exhibit empty cysts in the epidermis following loss of telogen club hairs
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• at weaning mice loss the hair on their backs and progressively lose the hair on their heads and tails
• mice specifically lose telogen hairs
• however, hair does grow back
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• mice exhibit blistering with acantholysis just above the basal cell layer with later stages exhibiting lateral separation of the basal keratinocytes
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• in severe cases adult mice exhibit complete loss of the epidermis in large sections
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• adult mice exhibit severe epidermal hyperplasia
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• 10% of mice develop blisters within hours of birth
• even careful handling of mice induces blisters on the skin
• however, no blisters are observed on internal stratified epithelia
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• all adult mice develop severe skin lesions
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/07/2024 MGI 6.23 |
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