All Phenotypes Adam10<tm1.1Zhu> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Adam10^tm1.1Zhu
targeted mutation 1.1, Yuan Zhuang
MGI:3809599

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Adam10^tm1.1Zhu/Adam10^tm1.1Zhu	involves: 129S6/SvEvTac * C57BL/6 * SJL	MGI:3809606
cn2	Adam10^tm1Zhu/Adam10^tm1.1Zhu Tg(Lck-cre)#Zhu/0	involves: 129S6/SvEvTac * C57BL/6 * SJL * SJL/J	MGI:3809608

Allelic Composition	Adam10^tm1.1Zhu/Adam10^tm1.1Zhu
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adam10^tm1.1Zhu mutation (0 available); any Adam10 mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:139042 )

• mice exhibit embryonic lethality around the same stage as reported for Adam10^tm1Psa homozygotes

Allelic Composition	Adam10^tm1Zhu/Adam10^tm1.1Zhu Tg(Lck-cre)#Zhu/0
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * SJL * SJL/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adam10^tm1.1Zhu mutation (0 available); any Adam10 mutation (39 available)
Adam10^tm1Zhu mutation (1 available); any Adam10 mutation (39 available)
Tg(Lck-cre)#Zhu mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

thymus hypoplasia ( J:139042 )

• thymic cellularity is decreased 2 to 3 fold compared to in wild-type mice

abnormal T cell differentiation ( J:139042 )

• thymocyte development is impaired

decreased double-positive T cell number ( J:139042 )

decreased CD4-positive, alpha-beta T cell number ( J:139042 )

hematopoietic system

thymus hypoplasia ( J:139042 )

• thymic cellularity is decreased 2 to 3 fold compared to in wild-type mice

abnormal T cell differentiation ( J:139042 )

• thymocyte development is impaired

decreased double-positive T cell number ( J:139042 )

decreased CD4-positive, alpha-beta T cell number ( J:139042 )

endocrine/exocrine glands

thymus hypoplasia ( J:139042 )

• thymic cellularity is decreased 2 to 3 fold compared to in wild-type mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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