Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Adam10tm1Psa
Name:	a disintegrin and metallopeptidase domain 10; targeted mutation 1, Paul Saftig
MGI ID:	MGI:3522353
Synonyms:	Adam10-
Gene:	Adam10  Location: Chr9:70586279-70687511 bp, + strand  Genetic Position: Chr9, 39.53 cM
Alliance:	Adam10tm1Psa page

Germline Transmission:	Earliest citation of germline transmission: J:94943
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: The 5' exon was interrupted by the insertion of a neomycin expression cassette. This introduces a premature stop codon into the ORF. RT-PCR and Northern blot analysis confirmed the absence of transcription. Western blot analysis demonstrated the absence of a protein product. (J:94943)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

9 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Adam10 Mutation:	37 strains or lines available

Original:	J:94943 Hartmann D, et al., The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts. Hum Mol Genet. 2002 Oct 1;11(21):2615-24
All:	12 reference(s)