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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(tetO-Myt1)2Ggu
transgene insertion 2, Guoqiang Gu
MGI:3809520
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Neurog3tm1.1(cre/ERT)Ggu/Neurog3+
Pdx1tm1Macd/Pdx1+
Tg(tetO-Myt1)2Ggu/0 		involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ MGI:3809541
cx2
 		Pdx1tm1Macd/Pdx1+
Tg(tetO-Myt1)2Ggu/0 		involves: 129S1/Sv * 129X1/SvJ MGI:3809543


Genotype
MGI:3809541
cn1
Allelic
Composition		 Neurog3tm1.1(cre/ERT)Ggu/Neurog3+
Pdx1tm1Macd/Pdx1+
Tg(tetO-Myt1)2Ggu/0
Genetic
Background		 involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Neurog3tm1.1(cre/ERT)Ggu mutation (0 available); any Neurog3 mutation (18 available)
Pdx1tm1Macd mutation (1 available); any Pdx1 mutation (35 available)
Tg(tetO-Myt1)2Ggu mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal pancreatic islet morphology ( J:136131 )
• fewer cells are induced to produce glucagons than in Pdx1tm1Macd/Pdx1+ Tg(tetO-Neurog3)8Ggu mice




Genotype
MGI:3809543
cx2
Allelic
Composition		 Pdx1tm1Macd/Pdx1+
Tg(tetO-Myt1)2Ggu/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdx1tm1Macd mutation (1 available); any Pdx1 mutation (35 available)
Tg(tetO-Myt1)2Ggu mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal pancreas development ( J:136131 )
• mice exhibit precocious endocrine differentiation, converting 1.8-fold more pancreatic cells to glucagon producing, immature alpha cells at E11.5 than in Pdx1tm1Macd heterozygotes
• however, this conversion is not sustained later in development as E18.5, only rare glucagons producing cells are found




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory