Phenotypes associated with this allele

• Allele Symbol: Tg(HLA-DRA*0101,HLA-DRB1*0101)1Dmz
• Allele Name: transgene insertion 1, Dennis M Zaller
• Allele ID: MGI:3809457
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Prkdc^scid/Prkdc^scid Tg(HLA-DRA*0101,HLA-DRB1*0101)1Dmz/Tg(HLA-DRA*0101,HLA-DRB1*0101)1Dmz	NOD.Cg-Tg(HLA-DRA*0101,HLA-DRB1*0101)1Dmz Prkdc^scid/Gck	MGI:3809476
tg2	Tg(HLA-DRA*0101,HLA-DRB1*0101)1Dmz/Tg(HLA-DRA*0101,HLA-DRB1*0101)1Dmz	involves: C57BL/6 * C57BL/10Sn * SJL/J	MGI:3809475

Genotype
MGI:3809476

cx1

• Allelic Composition: Prkdc^scid/Prkdc^scid; Tg(HLA-DRA*0101,HLA-DRB1*0101)1Dmz/Tg(HLA-DRA*0101,HLA-DRB1*0101)1Dmz
• Genetic Background: NOD.Cg-Tg(HLA-DRA*0101,HLA-DRB1*0101)1Dmz Prkdc^scid/Gck

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

extended life span ( J:126700 )

• these mice live significantly longer than NOD/scid mice that do not carry the transgene

• the mean lifespan for these mice is 420.5 days compared to 247.6 days for NOD/scid controls

• controls die of thymic or splenic lymphoma

immune system

absent T cells ( J:126700 )

• T cells are absent in these mice

abnormal professional antigen presenting cell morphology ( J:126700 )

• 10-12% of peripheral blood mononuclear cells express the chimeric MHC complex

hematopoietic system

absent T cells ( J:126700 )

• T cells are absent in these mice

Genotype
MGI:3809475

tg2

• Allelic Composition: Tg(HLA-DRA*0101,HLA-DRB1*0101)1Dmz/Tg(HLA-DRA*0101,HLA-DRB1*0101)1Dmz
• Genetic Background: involves: C57BL/6 * C57BL/10Sn * SJL/J

immune system

abnormal T cell physiology ( J:108635 )

• T cells from mice immunized with human collagen have higher responses to collagen-derived peptides

• in almost all cases, these peptides need to be presented by the transgenic MHC-complex and not the endogenous MHC to elicit a response

increased susceptibility to induced arthritis ( J:108635 )

• mice are highly susceptible to arthritis induced by human collagen with incidence rates between 88% to 100% by 50 days post-injection

• mice have marked swelling and erythema of the hind and fore paws after human collagen administration

• inflammation frequently includes the wrist and ankle with massive infiltration of inflammatory cells leading to erosion of articular surfaces

• littermate control mice do not develop disease when injected human collagen

increased autoantibody level ( J:108635 )

• mice immunized with human collagen produce at least 5-fold more antibody to mouse collagen than do non-transgenic controls

skeleton

increased susceptibility to induced arthritis ( J:108635 )

• mice are highly susceptible to arthritis induced by human collagen with incidence rates between 88% to 100% by 50 days post-injection

• mice have marked swelling and erythema of the hind and fore paws after human collagen administration

• inflammation frequently includes the wrist and ankle with massive infiltration of inflammatory cells leading to erosion of articular surfaces

• littermate control mice do not develop disease when injected human collagen

hematopoietic system

abnormal T cell physiology ( J:108635 )

• T cells from mice immunized with human collagen have higher responses to collagen-derived peptides

• in almost all cases, these peptides need to be presented by the transgenic MHC-complex and not the endogenous MHC to elicit a response

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
rheumatoid arthritis		DOID:7148	OMIM:180300	J:108635