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Transgene Detail
Symbol: Tg(HLA-DRA*0101,HLA-DRB1*0101)1Dmz
Name: transgene insertion 1, Dennis M Zaller
MGI ID: MGI:3809457
Synonyms: DR1, DR1 Tg, HLA-DR1, Tg(HLA-DRB1*01)1Dmz
Transgene: Tg(HLA-DRA*0101,HLA-DRB1*0101)1Dmz  Location: unknown  Genetic Position: Chr5, Syntenic
Alliance: Tg(HLA-DRA*0101,HLA-DRB1*0101)1Dmz page
Strain of Origin:  (C57BL/6 x SJL/J)F2
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Mutation detailsA chimeric MHC class II complex was created by fusing the human peptide binding domains of class II alpha and beta chains to the CD4 binding domains of murine class II alpha or beta chains. The was done by the construction of two separate transgene constructs. The alpha1 and beta1 domains isolated from human DRA1*0101 and DRB1*0101 replaced the corresponding alpha1 and beta1 domains of the H2-Ea and H2-Eb1 genes that make up mouse I-Ed. The native murine promoters were left intact. These transgene constructs were co-injected into fertilized oocytes and the founder mice with the highest expression of the chimeric MHC was chosen for further propagation. Flow cytometry analysis indicates that virtually all cells in peripheral blood that express endogenous MHC-II also express the chimeric MHC-II. The transgene construct was later shown (in J:126700) to have inserted into chromosome 5. (J:108635, J:126700)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Original:  J:108635 Rosloniec EF, et al., An HLA-DR1 transgene confers susceptibility to collagen-induced arthritis elicited with human type II collagen. J Exp Med. 1997 Mar 17;185(6):1113-22
All:  17 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory