Analysis Tools
mortality/aging
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• mice die by 6 to 7 days after birth
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digestive/alimentary system
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• at E14.5, no acinar cells are detected unlike in wild-type mice
• by E18.5, few acinar cells appear in late embryonic development
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• mice exhibit impaired milk digestion
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growth/size/body
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• moderate at birth
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endocrine/exocrine glands
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• at birth the pancreas is small and altered compared to in wild-type mice
• unlike in wild-type mice, the duodenal part of the pancreas exhibits weak branching and the splenic part exhibits no branching
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• at E14.5, no acinar cells are detected unlike in wild-type mice
• by E18.5, few acinar cells appear in late embryonic development
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• at E11.5, mice exhibit an increase in glucagon producing cells
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• the number of islets is decreased compared to wild-type mice
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• the endocrine epithelium is disrupted with alpha cells not surrounded by beta cells and long rather than circular islet-like structures
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• at E13.5, the pancreatic epithelial mass is reduced and pancreatic bud branching is weaker than in wild-type mice
• mice exhibit a 40% decrease in the number of proliferating cells compared to in wild-type mice
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• at E11.5, mice exhibit premature differentiation into endocrine cells
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cellular
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• at E11.5, mice exhibit premature differentiation into endocrine cells
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