Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
E2f3tm2.1Gle mutation
(0 available);
any
E2f3 mutation
(32 available)
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mortality/aging
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N |
• unlike mice lacking both isoforms, in mice lacking only the E2f3a isoform no significant embryonic lethality is seen
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
E2f3tm2.1Gle mutation
(0 available);
any
E2f3 mutation
(32 available)
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adipose tissue
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• in older mice compared to age-matched wild-type mice
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mortality/aging
cellular
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• in MEFs after 5 and 6 days in culture compared to littermate-derived controls
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
E2f2tm1Zubi mutation
(1 available);
any
E2f2 mutation
(29 available)
E2f3tm2.1Gle mutation
(0 available);
any
E2f3 mutation
(32 available)
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normal phenotype
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• born at the expected frequency, normal birth weights and mature without obvious defects
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
E2f1tm1Meg mutation
(2 available);
any
E2f1 mutation
(25 available)
E2f3tm2.1Gle mutation
(0 available);
any
E2f3 mutation
(32 available)
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mortality/aging
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• only a few mice survive beyond 1 month of age
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• most die within the first month of life
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adipose tissue
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N |
• despite loss of white fat, brown fat is relatively unaffected
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• by 3 weeks of age all white adipose deposits are absent
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behavior/neurological
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N |
• no defect in eating behavior is detected, despite the absence of white fat
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digestive/alimentary system
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N |
• no defect in fat absorption is detected, despite the absence of white fat
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growth/size/body
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• severely runted by 3 weeks of age
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homeostasis/metabolism
cellular
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• by 3 weeks of age the proliferative index in most tissues is reduced
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reproductive system
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• lack a well-developed corpus luteum
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• the few females that reach reproductive age are infertile
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• the few males that reach reproductive age are infertile
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skeleton
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• at P21, long bone growth plates are severely dysplastic with many cells having mega-nuclei
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endocrine/exocrine glands
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• the outer cortex lacks a functional zona fasciculata
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• lack a well-developed corpus luteum
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nervous system
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• by 21 days of age there is a relative increase in the brain weight to body weight ratio
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respiratory system
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• decrease in the branching of the epithelium
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
E2f3tm2.1Gle mutation
(0 available);
any
E2f3 mutation
(32 available)
E2f7tm1.1Gle mutation
(0 available);
any
E2f7 mutation
(32 available)
E2f8tm1.1Gle mutation
(0 available);
any
E2f8 mutation
(34 available)
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embryo
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N |
• placentas appear normal with well-organized labyrinthine architecture and vasculature, and are functional as fetuses lack signs of acute stress response or ectopic cell apoptosis
• live embryos/fetuses are recovered at all stages analyzed, including at birth
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Analysis Tools
