About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rtn4rtm1.1Pado
targeted mutation 1.1, Patrick Doherty
MGI:3806671
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rtn4rtm1.1Pado/Rtn4rtm1.1Pado involves: 129S/SvEvBrd * 129S4/SvJae MGI:3806676
cx2
 		Rtn4rtm1.1Pado/Rtn4rtm1.1Pado
Rtn4rl1tm1.1Rojg/Rtn4rl1tm1.1Rojg
Rtn4rl2tm1.1Pado/Rtn4rl2tm1.1Pado 		involves: 129S/SvEvBrd * 129S4/SvJae MGI:5462102
cx3
 		Rtn4rtm1.1Pado/Rtn4rtm1.1Pado
Rtn4rl1tm1.1Rojg/Rtn4rl1tm1.1Rojg 		involves: 129S/SvEvBrd * 129S4/SvJae MGI:5462103
cx4
 		Ptprstm1Mtr/Ptprstm1Mtr
Rtn4rtm1.1Pado/Rtn4rtm1.1Pado
Rtn4rl1tm1.1Rojg/Rtn4rl1tm1.1Rojg 		involves: 129S/SvEvBrd * 129S4/SvJae MGI:5462104
cx5
 		Rtn4rtm1.1Pado/Rtn4rtm1.1Pado
Rtn4rl2tm1.1Pado/Rtn4rl2tm1.1Pado 		involves: 129S/SvEvBrd * 129S4/SvJae MGI:5462105


Genotype
MGI:3806676
hm1
Allelic
Composition		 Rtn4rtm1.1Pado/Rtn4rtm1.1Pado
Genetic
Background		 involves: 129S/SvEvBrd * 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rtn4rtm1.1Pado mutation (0 available); any Rtn4r mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal axon extension ( J:138580 )
• unlike in wild-type mice, neurite outgrowth is not sensitive to treatment with trisialoganglioside (GT1b) antibodies or soluble MAG

cellular
abnormal axon extension ( J:138580 )
• unlike in wild-type mice, neurite outgrowth is not sensitive to treatment with trisialoganglioside (GT1b) antibodies or soluble MAG




Genotype
MGI:5462102
cx2
Allelic
Composition		 Rtn4rtm1.1Pado/Rtn4rtm1.1Pado
Rtn4rl1tm1.1Rojg/Rtn4rl1tm1.1Rojg
Rtn4rl2tm1.1Pado/Rtn4rl2tm1.1Pado
Genetic
Background		 involves: 129S/SvEvBrd * 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rtn4rl1tm1.1Rojg mutation (0 available); any Rtn4rl1 mutation (24 available)
Rtn4rl2tm1.1Pado mutation (0 available); any Rtn4rl2 mutation (22 available)
Rtn4rtm1.1Pado mutation (0 available); any Rtn4r mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
enhanced central nervous system regeneration ( J:191258 )
• modestly improved recovery of retinal ganglion cell axons from retro-orbital optic nerve crush
abnormal neuron physiology ( J:191258 )
• cerebellar granule neurons experience significant but incomplete release of growth inhibition in culture
• strong inhibition of neuron growth when challenged with high concentrations of chondroitin sulfate proteoglycans
• neurites are significantly longer than those of any controls




Genotype
MGI:5462103
cx3
Allelic
Composition		 Rtn4rtm1.1Pado/Rtn4rtm1.1Pado
Rtn4rl1tm1.1Rojg/Rtn4rl1tm1.1Rojg
Genetic
Background		 involves: 129S/SvEvBrd * 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rtn4rl1tm1.1Rojg mutation (0 available); any Rtn4rl1 mutation (24 available)
Rtn4rtm1.1Pado mutation (0 available); any Rtn4r mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
enhanced central nervous system regeneration ( J:191258 )
• modestly improved recovery of retinal ganglion cell axons from retro-orbital optic nerve crush




Genotype
MGI:5462104
cx4
Allelic
Composition		 Ptprstm1Mtr/Ptprstm1Mtr
Rtn4rtm1.1Pado/Rtn4rtm1.1Pado
Rtn4rl1tm1.1Rojg/Rtn4rl1tm1.1Rojg
Genetic
Background		 involves: 129S/SvEvBrd * 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptprstm1Mtr mutation (0 available); any Ptprs mutation (78 available)
Rtn4rl1tm1.1Rojg mutation (0 available); any Rtn4rl1 mutation (24 available)
Rtn4rtm1.1Pado mutation (0 available); any Rtn4r mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
enhanced central nervous system regeneration ( J:191258 )
• considerably improved recovery of retinal ganglion cell axons from retro-orbital optic nerve crush




Genotype
MGI:5462105
cx5
Allelic
Composition		 Rtn4rtm1.1Pado/Rtn4rtm1.1Pado
Rtn4rl2tm1.1Pado/Rtn4rl2tm1.1Pado
Genetic
Background		 involves: 129S/SvEvBrd * 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rtn4rl2tm1.1Pado mutation (0 available); any Rtn4rl2 mutation (22 available)
Rtn4rtm1.1Pado mutation (0 available); any Rtn4r mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:191258 )
N
• no improvement relative to controls in recovery of retinal ganglion cell axons from retro-orbital optic nerve crush




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory