Ptprs^tm1Mtr
Targeted Allele Detail

Summary

• Symbol: Ptprs^tm1Mtr
• Name: protein tyrosine phosphatase receptor type S; targeted mutation 1, Michel L Tremblay
• MGI ID: MGI:2158757
• Synonyms: Ptprs-, RPTPsigma(-)
• Gene: Ptprs Location: Chr17:56719426-56783480 bp, - strand Genetic Position: Chr17, 29.32 cM
• Alliance: Ptprs^tm1Mtr page

Craniofacial anomalies in Ptprf^tm1Wjh/Ptprf^tm1Wjh Ptprs^tm1Mtr/Ptprs^tm1Mtr double-mutant embryos

Show the 5 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:53434
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced sequences encoding amino acids 1399-1518 in the intracellular domain, including sequences encoding a conserved CAQYWP motif present in the first PTPase catalytic domain. Northern blot analysis of brain using a probe corresponding to nt 320-1201 of the cDNA sequence did not detect transcript in homozygous mutant newborn mice. Western blot analysis did not detect protein in brain from homozygous mutant newborn mice. (J:53434)

Disease models

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptprs Mutation: 78 strains or lines available

References

• Original: J:53434 Elchebly M, et al., Neuroendocrine dysplasia in mice lacking protein tyrosine phosphatase sigma. Nat Genet. 1999 Mar;21(3):330-3
• All: 18 reference(s)