Phenotypes associated with this allele

• Allele Symbol: Id2^tm1Ago
• Allele Name: targeted mutation 1, Ananda W Goldrath
• Allele ID: MGI:3806370
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Id2^tm1Ago/Id2^tm1Ago	B6.129-Id2^tm1Ago	MGI:3806451
cx2	Id2^tm1Ago/Id2^tm1Ago Tg(TcraTcrb)1100Mjb/0	B6.Cg-Id2^tm1Ago Tg(TcraTcrb)1100Mjb	MGI:3806453

Genotype
MGI:3806451

hm1

• Allelic Composition: Id2^tm1Ago/Id2^tm1Ago
• Genetic Background: B6.129-Id2^tm1Ago

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:138276 )

• die by 2 weeks of age

immune system

absent NK cells ( J:116119 )

decreased CD8-positive, alpha-beta T cell number ( J:116119 )

• lack several CD8+ splenocyte subsets corresponding to an effector memory phenotype

• however, there is no difference in the percentage of cells with a central memory phenotype

absent lymph nodes ( J:116119 )

adipose tissue

adipose tissue phenotype ( J:138276 )

N • despite the reduction in white adipose tissue, the size and morphology of adipocytes is normal

decreased white adipose tissue amount ( J:138276 )

• at P6

decreased inguinal fat pad weight ( J:138276 )

• relative deficiency at P4

decreased interscapular fat pad weight ( J:138276 )

• relative deficiency at P4

cellular

abnormal cell differentiation ( J:138276 )

• MEFs display a modest but reproducible reduction in adipogenic potential

growth/size/body

decreased body size ( J:138276 )

• noticeably runted by P6

hematopoietic system

absent NK cells ( J:116119 )

decreased CD8-positive, alpha-beta T cell number ( J:116119 )

• lack several CD8+ splenocyte subsets corresponding to an effector memory phenotype

• however, there is no difference in the percentage of cells with a central memory phenotype

Genotype
MGI:3806453

cx2

• Allelic Composition: Id2^tm1Ago/Id2^tm1Ago; Tg(TcraTcrb)1100Mjb/0
• Genetic Background: B6.Cg-Id2^tm1Ago Tg(TcraTcrb)1100Mjb

immune system

abnormal T cell activation ( J:116119 )

• adoptive transfer studies indicate that there is impaired accumulation of effector CD8+ T cells possibly because of an increase in apoptosis in these cells with surviving cells developing a central memory-like phenotype

hematopoietic system

abnormal T cell activation ( J:116119 )

• adoptive transfer studies indicate that there is impaired accumulation of effector CD8+ T cells possibly because of an increase in apoptosis in these cells with surviving cells developing a central memory-like phenotype