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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(tetO-SOD1*G93A,-luc)1Roos
transgene insertion 1, Raymond Roos
MGI:3806292
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Gt(ROSA)26Sortm1(tTA)Roos/?
Lhx3tm1(cre)Slp/Lhx3+
Tg(tetO-SOD1*G93A,-luc)1Roos/0
involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 MGI:3806328


Genotype
MGI:3806328
cn1
Allelic
Composition
Gt(ROSA)26Sortm1(tTA)Roos/?
Lhx3tm1(cre)Slp/Lhx3+
Tg(tetO-SOD1*G93A,-luc)1Roos/0
Genetic
Background
involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(tTA)Roos mutation (3 available); any Gt(ROSA)26Sor mutation (944 available)
Lhx3tm1(cre)Slp mutation (0 available); any Lhx3 mutation (25 available)
Tg(tetO-SOD1*G93A,-luc)1Roos mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• mice show no significant differences relative to triple mutants carrying wild-type human SOD1, in the rotarod test when tested at 300 days and later
• significant decrease in number of spinal motor neurons (MNs) compared to wild-type and transgenic controls is observed at 450 days of age
• significant decrease in number of axons in L5 anterior root at 450 days is observed compared to triple mutants expressing wild-type human SOD1

growth/size/body
• after 300 days, mean body weight is reduced relative to wild-type or to triple mutants carrying the wild-type human SOD1 gene





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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory