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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Myh6-Tnnt2*)1Feah
transgene insertion 1, Fehaan Ahmad
MGI:3805021
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Tg(Myh6-Tnnt2*)1Feah/0
Tnnt2tm1Feah/Tnnt2+ 		involves: 129S/SvEv * 129S6/SvEvTac * FVB/N MGI:3805039
tg2
 		Tg(Myh6-Tnnt2*)1Feah/0 129S.FVB-Tg(Myh6-Tnnt2*)1Feah MGI:3805038


Genotype
MGI:3805039
cx1
Allelic
Composition		 Tg(Myh6-Tnnt2*)1Feah/0
Tnnt2tm1Feah/Tnnt2+
Genetic
Background		 involves: 129S/SvEv * 129S6/SvEvTac * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Myh6-Tnnt2*)1Feah mutation (0 available)
Tnnt2tm1Feah mutation (0 available); any Tnnt2 mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
dilated heart ( J:137964 )
• massive
dilated cardiomyopathy ( J:137964 )
• mice exhibit severe dilated cardiomyopathy
• left ventricular end diastolic diameter is increased compared to in heterozygous mice with a wild-type transgene
increased heart rate ( J:137964 )
• non-sustained tachycardia was induced in 2 of 5 mice compared to only 1 of 10 wild-type mice
abnormal myocardial fiber physiology ( J:137964 )
• mice exhibit myofiber calcium desensitization
congestive heart failure ( J:137964 )
• evident by molecular markers

muscle
dilated cardiomyopathy ( J:137964 )
• mice exhibit severe dilated cardiomyopathy
• left ventricular end diastolic diameter is increased compared to in heterozygous mice with a wild-type transgene




Genotype
MGI:3805038
tg2
Allelic
Composition		 Tg(Myh6-Tnnt2*)1Feah/0
Genetic
Background		 129S.FVB-Tg(Myh6-Tnnt2*)1Feah
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
dilated cardiomyopathy ( J:137964 )
• dilated cardiomyopathy is mild at 9 weeks of age
• however, electrocardiogram telemetry, cardiac electrophysiology and heart histology are normal

muscle
dilated cardiomyopathy ( J:137964 )
• dilated cardiomyopathy is mild at 9 weeks of age
• however, electrocardiogram telemetry, cardiac electrophysiology and heart histology are normal




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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory