Tnnt2^tm1Feah
Targeted Allele Detail

Summary

• Symbol: Tnnt2^tm1Feah
• Name: troponin T2, cardiac; targeted mutation 1, Ferhaan Ahmad
• MGI ID: MGI:3805012
• Gene: Tnnt2 Location: Chr1:135764092-135779998 bp, + strand Genetic Position: Chr1, 59.32 cM
• Alliance: Tnnt2^tm1Feah page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:137964
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 14 was replaced with a floxed neo cassette. Germ line, cre mediated recombination was used to remove the neo cassette. The absence of transcript expression was confirmed by northern blot analysis on embryo extracts. (J:137964)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tnnt2 Mutation: 52 strains or lines available

References

• Original: J:137964 Ahmad F, et al., The role of cardiac troponin T quantity and function in cardiac development and dilated cardiomyopathy. PLoS One. 2008;3(7):e2642
• All: 1 reference(s)