About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fgf16tm1Paca
targeted mutation 1, Peter A Cattini
MGI:3804709
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Fgf16tm1Paca/Fgf16tm1Paca involves: 129S1/Sv * 129X1/SvJ * Black Swiss MGI:3806241
ot2
 		Fgf16tm1Paca/Y involves: 129S1/Sv * 129X1/SvJ * Black Swiss MGI:3805380


Genotype
MGI:3806241
hm1
Allelic
Composition		 Fgf16tm1Paca/Fgf16tm1Paca
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf16tm1Paca mutation (0 available); any Fgf16 mutation (9 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:138004 )
• no homozygous female embryos are born




Genotype
MGI:3805380
ot2
Allelic
Composition		 Fgf16tm1Paca/Y
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf16tm1Paca mutation (0 available); any Fgf16 mutation (9 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:138004 )
• mice are normal up to E10.5
• all hemizygous male mice die between E10.5 and E12.5
• growth retarded or resorbing at E12.5

embryo
abnormal first pharyngeal arch morphology ( J:138004 )
• failure of the upper pharyngeal arch to fuse to the upper mandible
embryonic growth retardation ( J:138004 )
• growth retarded at E12.5

cardiovascular system
cardiovascular system phenotype ( J:138004 )
N
• cardiac morphology normal at E9.5
dilated heart atrium ( J:138004 )
• both atrial lumina enlarged at E11.5
trabecula carnea hypoplasia ( J:138004 )
• development compromised at E10.5
• poor trabeculation at E11.5, particularly in the right part of the ventricle
dilated heart ventricle ( J:138004 )
• dilation of common ventricle at E10.5
• enlarged lumen at E11.5 in embryos still alive
internal hemorrhage ( J:138004 )
• in and around the cardiac and ventral body regions

growth/size/body
embryonic growth retardation ( J:138004 )
• growth retarded at E12.5

craniofacial
abnormal first pharyngeal arch morphology ( J:138004 )
• failure of the upper pharyngeal arch to fuse to the upper mandible

muscle
trabecula carnea hypoplasia ( J:138004 )
• development compromised at E10.5
• poor trabeculation at E11.5, particularly in the right part of the ventricle




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory