All Phenotypes Fgf16<tm1Paca> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Fgf16^tm1Paca
targeted mutation 1, Peter A Cattini
MGI:3804709

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fgf16^tm1Paca/Fgf16^tm1Paca	involves: 129S1/Sv * 129X1/SvJ * Black Swiss	MGI:3806241
ot2	Fgf16^tm1Paca/Y	involves: 129S1/Sv * 129X1/SvJ * Black Swiss	MGI:3805380

Allelic Composition	Fgf16^tm1Paca/Fgf16^tm1Paca
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * Black Swiss

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf16^tm1Paca mutation (0 available); any Fgf16 mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:138004 )

• no homozygous female embryos are born

Allelic Composition	Fgf16^tm1Paca/Y
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * Black Swiss

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf16^tm1Paca mutation (0 available); any Fgf16 mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:138004 )

• mice are normal up to E10.5

• all hemizygous male mice die between E10.5 and E12.5

• growth retarded or resorbing at E12.5

embryo

abnormal first pharyngeal arch morphology ( J:138004 )

• failure of the upper pharyngeal arch to fuse to the upper mandible

embryonic growth retardation ( J:138004 )

• growth retarded at E12.5

cardiovascular system

cardiovascular system phenotype ( J:138004 )

N	• cardiac morphology normal at E9.5

abnormal heart morphology ( J:138004 )

dilated heart atrium ( J:138004 )

• both atrial lumina enlarged at E11.5

abnormal heart ventricle morphology ( J:138004 )

trabecula carnea hypoplasia ( J:138004 )

• development compromised at E10.5

• poor trabeculation at E11.5, particularly in the right part of the ventricle

thin ventricular wall ( J:138004 )

• at E11.5

dilated heart ventricle ( J:138004 )

• dilation of common ventricle at E10.5

• enlarged lumen at E11.5 in embryos still alive

internal hemorrhage ( J:138004 )

• in and around the cardiac and ventral body regions

growth/size/body

embryonic growth retardation ( J:138004 )

• growth retarded at E12.5

craniofacial

abnormal first pharyngeal arch morphology ( J:138004 )

• failure of the upper pharyngeal arch to fuse to the upper mandible

muscle

trabecula carnea hypoplasia ( J:138004 )

• development compromised at E10.5

• poor trabeculation at E11.5, particularly in the right part of the ventricle

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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